Flat fluidics: a new route toward programmable biochips
Flat fluidics: a new route toward programmable biochips
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平面流体学：可编程生物芯片的新途径
DOI：
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发表时间：
2003
期刊：
影响因子：
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通讯作者：
R. Kirchner
中科院分区：
文献类型：
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作者：
A. Wixforth;C. Gauer;J. Scriba;M. Wassermeier;R. Kirchner
The miniaturization of chemical and biological processes has made enormous progress driven mainly by genomics and proteomics. Microfluidics is the core technology to realize miniaturized laboratories with feature sizes on a submillimeter scale. Here, we report on a novel microfluidic technology which allows biochips to be programmed so that different biological assays can be performed with only one chip layout. Interdigital transducers integrated on piezoelectric substrates excite surface acoustic waves (SAW) which drive reagents on the surface of the biochip. The reagents can be placed on any desired spot on the chip’s surface, they can be merged, split and brought to reaction. SAW technology can also be used to efficiently agitate small volumes of liquids accelerating diffusion limited reactions considerably.
