Polyamines and colon cancer.
Polyamines and colon cancer.
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DOI：
10.1097/00042737-200109000-00006
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发表时间：
2001-09
影响因子：
2.1
通讯作者：
H. Wallace;R. Caslake
中科院分区：
文献类型：
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作者：
H. Wallace;R. Caslake
结直肠癌是西方世界的一个主要健康问题，与显着的发病率和死亡率相关。饮食对这种疾病有重大影响，高脂肪、低纤维饮食与结直肠癌的高发病率呈正相关。在结直肠癌组织和癌前息肉中，细胞内多胺浓度和鸟氨酸脱羧酶活性均增加。有人提出测量个体血清和尿液中的多胺含量作为恶性肿瘤的诊断标志物，但许多假阳性使这一想法站不住脚。然而，作为监测治疗效果的一种手段，测量尿多胺含量可能仍然发挥作用。通过多胺类似物或通过非甾体抗炎药抑制多胺代谢可用于结直肠癌的化疗和/或化学预防。初步结果表明，低多胺饮食可能有助于癌症患者医疗保健计划的一部分。
Colorectal cancer is a major health problem in the western world and is associated with significant morbidity and mortality. Diet makes a significant contribution to the disease, with high fat, low fibre diets correlating positively with a high incidence of colorectal cancer. Intracellular polyamine concentrations and ornithine decarboxylase activity are both increased in colorectal cancer tissue and in premalignant polyps. Measurement of the polyamine content of serum and urine of individuals has been proposed as a diagnostic marker of malignancy but a number of false positives make this idea untenable. There may, however, still be a role for the measurement of urinary polyamine content as a means of monitoring the efficacy of therapy. Inhibition of polyamine metabolism by polyamine analogues or by non-steroidal anti-inflammatory drugs may be useful in the chemotherapy and/or chemoprevention of colorectal cancer. Preliminary results suggest that a low polyamine diet might be helpful as part of a health care plan for cancer patients.