Functional connectivity among limbic brain areas: differential effects of incubation temperature and gonadal sex in the leopard gecko, Eublepharis macularius.
Functional connectivity among limbic brain areas: differential effects of incubation temperature and gonadal sex in the leopard gecko, Eublepharis macularius.
复制标题
边缘脑区域之间的功能连接：孵化温度和性腺性别对豹纹壁虎 Eublepharis macularius 的不同影响。
DOI：
10.1159/000006648
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Crews,D
中科院分区：
文献类型：
--
作者：
Sakata,JT;Coomber,P;Gonzalez-Lima,F;Crews,D
行为个体差异的神经基础主要通过分析特定神经区域的特性来研究。然而，由于神经系统的组织，行为的差异也可能是由大脑核团（特别是神经回路）之间的交互性或功能连接的差异介导的。在豹纹壁虎（Eublepharis macularius）中，卵孵化期间的温度不仅决定性腺性别，而且还塑造了成年动物的社会性行为，生殖生理和激素敏感性。在这项研究中，孵化温度和性腺性别对边缘脑区之间的功能连接的影响进行了研究。通过分析代谢能力的协方差模式评估功能连接，如定量细胞色素氧化酶组织化学所示。据推测，孵化温度和性腺性别通过改变相关神经回路内的功能连接性来影响表现出攻击性或性行为的倾向。下丘脑前部与隔区和视前区之间的代谢能力的相关性仅在相对攻击性个体中显著，表明这些回路可能调节由孵育温度引起的攻击性的表型变化。下丘脑腹内侧核与背侧脑室嵴和隔之间的相关性仅在女性中显著，表明这些回路可能调节女性典型的性行为。视前区，下丘脑和杏仁核区域之间的相关性往往分布在两种性别，这表明可能有共同的途径，男性典型和女性典型的行为的表达。
The neural basis of individual differences in behavior has been studied primarily by analyzing the properties of specific neural areas. However, because of the organization of the nervous system, it is also plausible that differences in behavior are mediated by differences in the interactivity or functional connectivity among brain nuclei in particular neural circuits. In the leopard gecko,Eublepharis macularius,the temperature of the egg during incubation not only determines gonadal sex, but also shapes the sociosexual behaviors, reproductive physiology, and hormone sensitivity of adult animals. In this study the effects of both incubation temperature and gonadal sex on functional connectivity among limbic brain areas were examined. Functional connectivity was assessed by analyzing covariance patterns in metabolic capacity, as revealed by quantitative cytochrome oxidase histochemistry. It was hypothesized that incubation temperature and gonadal sex affect the propensity to display aggressive or sexual behaviors by altering the functional connectivity within relevant neural circuits. The correlations of metabolic capacity between the anterior hypothalamus and both the septum and preoptic area were significant only in relatively aggressive individuals, suggesting that these circuits may regulate the phenotypic variation in aggressiveness caused by incubation temperature. The correlations between the ventromedial hypothalamus and both the dorsal ventricular ridge and septum were significant only in females, suggesting that these circuits may modulate female-typical sexual behaviors. Correlations among preoptic, hypothalamic and amygdalar areas tended to be distributed across both sexes, suggesting that there may be shared pathways underlying the expression of male-typical and female-typical behaviors.