Heart rate variability in an ageing population and its association with lifestyle and cardiovascular risk factors:: results of the SAPALDIA study
Heart rate variability in an ageing population and its association with lifestyle and cardiovascular risk factors:: results of the SAPALDIA study
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DOI：
10.1093/europace/eul063
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发表时间：
2006-07-01
期刊：
影响因子：
6.1
通讯作者：
Ackermann-Liebrich, Ursula
中科院分区：
文献类型：
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作者：
Dietrich, Denise Felber;Schindler, Christian;Ackermann-Liebrich, Ursula
目的：（i）报告一般人群心血管危险因素与心率变异性（HRV）之间的关系，（ii）提供年龄≥ 50岁的健康欧洲一般人群样本中各种HRV测量的正常值。方法和结果（瑞士队列研究空气污染和成人肺部疾病）参与者年龄>= 50。在多变量回归分析中，与男性（n = 847）相比，女性（n = 895）的所有正常RR（NN）间期（SDNN）的标准差低6.1%，总功率（TP）低11.4%，双频（LF）功率低27.2%。BMI每增加一单位，SDNN下降0.7%，TP下降1.2%。高血压患者的LF比血压正常者低9.2%，目前吸烟者的LF比从不吸烟者低15.5%。每小时的剧烈体育锻炼与SDNN增加2.0%，高频（HF）范围功率增加3.6%和LF功率增加4.2%相关。高尿酸、高敏C反应蛋白和非高密度脂蛋白胆固醇水平与低TP、HF和LF相关。百分位数的TP和LF/HF作为年龄的函数进行计算的无症状的子样本的参与者（n = 499）免费的cardiactive medications.Conclusion心率变异性在一般人群样本显示预期的关联与所有已知的心血管危险因素，虽然不完全相同的所有HRV域。再加上我们对HRV作为年龄函数的百分位估计，这些发现可以帮助科学家解释24小时HRV值和影响老龄化人口的因素。
Aims (i) To report associations between cardiovascular risk factors and heart rate variability (HRV) in a general population and (ii) to provide normal values for various HRV measurements in a healthy European general population sample aged >= 50.Methods and results Twenty-four-hour electrocardiograms were recorded in 1742 randomly selected SAPALDIA (Swiss cohort study on Air Pollution and Lung Diseases in Adults) participants aged >= 50. In multivariate regression analyses, women (n = 895) had a 6.1% lower standard deviation of all normal RR (NN) intervals (SDNN), a 11.4% lower total power (TP), and a 27.2% lower tow-frequency (LF) power than men (n = 847). Per unit increase in BMI, SDNN decreased by 0.7% and TP decreased by 1.2%. Persons with high blood pressure had a 9.2% lower LF than normotensive persons and current smokers a 15.5% lower LF than never smokers. Each hour of heavy physical exercise was associated with a 2.0% increase in SDNN, a 3.6% increase in the high frequency (HF) range power and a 4.2% increase in LF power. Higher levels of uric acid, high-sensitive C-reactive protein and non-HDL-cholesterol were associated with lower TP, HF and LF. Percentiles of TP and LF/HF as a function of age were calculated for an asymptomatic subsample of participants (n = 499) free of cardioactive medications.Conclusion Heart rate variability in a general population sample shows expected associations with all known cardiovascular risk factors, although not identically for all HRV domains. Together with our percentile estimates for HRV as a function of age, these findings could assist scientists in interpreting 24 h HRV values and factors influencing them in an ageing population.