The correlation between plasma trimethylamine N-oxide level and heart failure classification in northern Chinese patients
The correlation between plasma trimethylamine N-oxide level and heart failure classification in northern Chinese patients
复制标题
中国北方患者血浆三甲胺N-氧化物水平与心力衰竭分级的相关性
DOI：
10.21037/apm-20-296
复制
发表时间：
2020-09-01
影响因子：
--
通讯作者：
Yu, Kaijiang
中科院分区：
文献类型：
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作者：
Dong, Zengxiang;Liang, Zhaoguang;Yu, Kaijiang
背景：三甲胺 N-氧化物（TMAO）已被确定为心血管疾病的新生物标志物。我们的目的是评估患有或不患有心力衰竭（HF）的患者血浆TMAO水平，并指出中国北方患者血浆TMAO水平与心力衰竭分类之间的相关性。方法：共有112名对照参与者和184名心力衰竭患者参与了本研究。对所有参与者的血浆TMAO和N端脑钠肽前体（NT-proBNP）水平进行检测和分析。结果：心力衰竭患者血浆TMAO水平显着高于对照组（7.0+/-0.6 vs. 1.5+/-0.1μmol/L；P
Background: Trimethylamine N-oxide (TMAO) has been identified as a new biomarker of cardiovascular disease. Our aim was to evaluate the plasma levels of TMAO in patients with or without heart failure (HF), and to indicate the correlation between plasma TMAO level and HF classification in northern Chinese patients.Methods: A total of 112 control participants and 184 HF patients participated in this study. Plasma levels of TMAO and N-terminal probrain natriuretic peptide (NT-proBNP) in all participants were examined and analyzed.Results: The plasma TMAO levels were remarkably higher in HF patients than that in control participants (7.0 +/- 0.6 vs. 1.5 +/- 0.1 mu mol/L; P