Catechol-Functionalized Synthetic Polymer as a Dental Adhesive to Contaminated Dentin Surface for a Composite Restoration.
Catechol-Functionalized Synthetic Polymer as a Dental Adhesive to Contaminated Dentin Surface for a Composite Restoration.
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DOI：
10.1021/acs.biomac.5b00451
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发表时间：
2015-08-10
影响因子：
6.2
通讯作者：
Kuroda K
中科院分区：
文献类型：
--
作者：
Lee SB;González-Cabezas C;Kim KM;Kim KN;Kuroda K
这项研究报告了一种用儿茶酚基团功能化的合成聚合物作为牙科粘合剂。我们假设儿茶酚官能化聚合物可作为湿牙本质表面的牙科粘合剂，有可能消除与唾液污染相关的并发症。我们制备了侧链含有儿茶酚和甲氧基乙基的无规共聚物。测定了在水和唾液成分存在下聚合物对牙本质表面的机械和粘合性能。结果发现，与不含该聚合物的对照样品相比，与 Fe3+ 添加剂相结合的新型聚合物提高了商业牙科粘合剂与人工唾液污染的牙本质表面的粘合强度。键合结构的组织学分析显示没有泄漏模式，这可能是由于铁-儿茶酚复合物的形成，它增强了键合结构。细胞毒性试验表明该聚合物不抑制人牙龈成纤维细胞的增殖。这项研究的结果表明，使用儿茶酚官能化聚合物作为牙科粘合剂可以减少由于唾液污染而导致的牙齿修复失败。
This study reports a synthetic polymer functionalized with catechol groups as dental adhesives. We hypothesize that a catechol-functionalized polymer functions as a dental adhesive for wet dentin surfaces, potentially eliminating the complications associated with saliva contamination. We prepared a random copolymer containing catechol and methoxyethyl groups in the side chains. The mechanical and adhesive properties of the polymer to dentin surface in the presence of water and salivary components were determined. It was found that the new polymer combined with an Fe3+ additive improved bond strength of a commercial dental adhesive to artificial saliva contaminated dentin surface as compared to a control sample without the polymer. Histological analysis of the bonding structures showed no leakage pattern, probably due to the formation of Fe–catechol complexes, which reinforce the bonding structures. Cytotoxicity test showed that the polymers did not inhibit human gingival fibroblast cells proliferation. Results from this study suggest a potential to reduce failure of dental restorations due to saliva contamination using catechol-functionalized polymers as dental adhesives.