C-Fos expression in the deep cerebellar nuclei in a rat model of conditioned fear
C-Fos expression in the deep cerebellar nuclei in a rat model of conditioned fear
复制标题
条件性恐惧大鼠模型小脑深部核团中 C-Fos 的表达
DOI：
10.5835/jecm.omu.29.03.007
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Y. Temel
中科院分区：
文献类型：
--
作者：
V. Moers;J. Vles;R. Hemmes;L. Lim;G. Hoogland;H. Steinbusch;Y. Temel
与以前的观点相反，越来越多的证据表明小脑参与了情感和认知行为。临床前和临床研究指出小脑在冲动和恐慌中的作用。大鼠中脑导水管周围灰质（dlPAG）的脑深部电刺激（DBS）已被证明可直接引起逃避行为，但也可用于情境依赖性恐惧反应的条件反射。我们用这个模型来研究条件性恐惧后小脑深核（DCbN）的激活。为此，我们在DCbN中进行c-Fos免疫组织化学。我们发现在该动物模型的亚组之间DCbN中的c-Fos表达没有统计学显著差异。我们假设，DCbN的激活缺乏显著差异可能与dlPAG刺激后发生的恐惧巩固有关，在此之后，行为的恢复，无论是适当的还是不适当的，都不会导致DCbN的不同激活。另一方面，条件性恐惧的影响可能小于DBS引起的恐慌行为的影响，需要更大的研究人群。
J. Exp.临床医学部，2012; 29：201-207
In contrast to what was previously believed, there is increasing evidence that the cerebellum is involved in emotional and cognitive behaviour. Preclinical and clinical research points towards a role of the cerebellum in impulsivity and panic. Deep brain stimulation (DBS) of the dorsolateral periaqueductal gray (dlPAG) in rats has proved to elicit escape behaviour directly, but can also be used for conditioning of context-dependant fear responses. We used this model to study the activation in the deep cerebellar nuclei (DCbN) after conditioned fear. For this purpose, we performed c-Fos immunohistochemistry in the DCbN. We found no statistically significant difference in c-Fos expression in the DCbN between the subgroups in this animal model. We hypothesize that the lack of a significant difference in activation of the DCbN may be related to fear consolidation which takes place after dlPAG stimulation, after which retrieval of behaviour, whether adequate or inadequate, does not lead to a different activation of the DCbN. On the other hand the effect of conditioned fear may be smaller than the effect of panic behaviour elicited by DBS, requiring a larger study population.
J. Exp. Clin. Med., 2012; 29:201-207
影响因子：
15.9
作者：
M. Rizzo
通讯作者：
M. Rizzo