Bone metastasis: mechanisms and therapeutic opportunities.
Bone metastasis: mechanisms and therapeutic opportunities.
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DOI：
10.1038/nrendo.2010.227
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发表时间：
2011-04
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--
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--
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骨骼是转移性癌症最常见的部位之一，并且来自乳腺或前列腺的肿瘤具有向该部位扩散的增加的倾向。骨骼中播散性肿瘤细胞的生长需要肿瘤细胞栖息在骨髓中，从而刺激局部骨细胞活性。肿瘤细胞与常驻骨和骨髓细胞之间的串扰破坏了正常的骨稳态，这导致肿瘤在骨中生长。转移性肿瘤细胞具有引发刺激骨吸收、骨形成或两者的反应的能力。这些活动的最终结果是严重的骨骼破坏，可能对患者造成可怕的后果。肿瘤转移到骨的这些痛苦且通常无法治愈的后果的分子机制开始被认识到，并且它们代表了有希望的新的治疗分子靶点。
The skeleton is one of the most common sites for metastatic cancer, and tumors arising from the breast or prostate possess an increased propensity to spread to this site. The growth of disseminated tumor cells in the skeleton requires tumor cells to inhabit the bone marrow, from which they stimulate local bone cell activity. Crosstalk between tumor cells and resident bone and bone marrow cells disrupts normal bone homeostasis, which leads to tumor growth in bone. The metastatic tumor cells have the ability to elicit responses that stimulate bone resorption, bone formation or both. The net result of these activities is profound skeletal destruction that can have dire consequences for patients. The molecular mechanisms that underlie these painful and often incurable consequences of tumor metastasis to bone are beginning to be recognized, and they represent promising new molecular targets for therapy.
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