Effect of proteins from beef, pork, and turkey meat on plasma and liver lipids of rats compared with casein and soy protein
Effect of proteins from beef, pork, and turkey meat on plasma and liver lipids of rats compared with casein and soy protein
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DOI：
10.1016/j.nut.2006.06.009
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发表时间：
2006-11-01
期刊：
影响因子：
4.4
通讯作者：
Eder, Klaus
中科院分区：
文献类型：
--
作者：
Brandsch, Corinna;Shukla, Anjali;Eder, Klaus
目的：我们评估了从牛肉、猪肉和火鸡肉中分离的膳食蛋白质对血浆、脂蛋白和肝脏中胆固醇和三酰基甘油浓度以及微粒体膜组成的影响（脂肪酸、磷脂酰胆碱/磷脂酰乙醇胺比率）与酪蛋白和大豆蛋白的比较。五组大鼠，每组12只，喂食半合成饲料20天，其中含有200 g/kg从牛肉、猪肉或火鸡肉中分离的蛋白质，或作为对照，酪蛋白或大豆蛋白。饲喂牛肉、猪肉或火鸡蛋白质的大鼠血浆、脂蛋白和肝脏的胆固醇浓度以及饲喂酪蛋白饮食的大鼠微粒体膜的组成没有差异。所有喂食动物来源蛋白质的组都比喂食大豆蛋白质的大鼠具有更高的极低密度脂蛋白（VLDL）和肝脏胆固醇浓度。然而，喂猪肉蛋白的大鼠肝脏，血浆和极低密度脂蛋白中的三酰甘油浓度较低，甾醇调节元件结合蛋白-1和葡萄糖-6-磷酸脱氢酶的mRNA浓度较低，比喂酪蛋白的大鼠。然而，血浆和极低密度脂蛋白三酰甘油在大鼠喂猪肉蛋白的浓度并不低，观察到在大鼠喂soyeprotein.Conclusion：蛋白质分离的牛肉，猪肉，或火鸡肉没有不同的酪蛋白胆固醇代谢的影响。与酪蛋白相比，猪肉蛋白降低血浆三酰甘油浓度，但与大豆蛋白相比没有降低。与酪蛋白相比，猪肉蛋白降低三酰甘油的作用被认为是由于肝脏脂肪酸合成减少所致。(C)2006年爱思唯尔公司All rights reserved.
Objective: We assessed the effect of dietary proteins isolated from beef, pork, and turkey meat on concentrations of cholesterol and triacyl glycerols in plasma, lipoproteins, and liver and the composition of the microsomal membrane (fatty acids, phosphatidylcholine/phosphatidylethanolamine ratio) compared with that of casein and soy protein in rats.Methods: Five groups of 12 rats each were fed semisynthetic diets for 20 d that contained 200 g/kg of proteins isolated from beef, pork, or turkey meat or, as controls, casein or soy protein.Results: Rats fed beef, pork, or turkey proteins did not differ in cholesterol concentrations of plasma, lipoproteins, and liver and in composition of microsomal membrane from rats fed the casein diet. All groups fed a protein from an animal source had higher very low-density lipoprotein (VLDL) and liver cholesterol concentrations than did rats fed soy protein. However, rats fed pork protein had lower concentrations of triacylglycerols in liver, plasma, and VLDL and lower mRNA concentrations of sterol regulatory element binding protein-1 and glucose-6-phosphate dehydrogenase than did rats fed casein. However, concentrations of plasma and VLDL triacylglycerols in rats fed pork protein were not as low as those observed in rats fed soy protein.Conclusion: Proteins isolated from beef, pork, or turkey meat do not differ from casein in their effects on cholesterol metabolism. Pork protein decreases plasma triacylglycerol concentrations compared with casein but not compared with soy protein. The triacylglycerol-lowering effect of pork protein compared with casein is suggested to be caused by decreased hepatic fatty acid synthesis. (C) 2006 Elsevier Inc. All rights reserved.