The regulatory functions of piRNA/PIWI in spermatogenesis
The regulatory functions of piRNA/PIWI in spermatogenesis
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DOI：
10.16288/j.yczz.17-245
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发表时间：
2017-08-01
期刊：
影响因子：
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通讯作者：
Zhao, Yanmei
中科院分区：
文献类型：
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作者：
Yuan, Zhiheng;Zhao, Yanmei
在动物生殖细胞中发现了一类24-32 nt的PIWI结合小非编码RNA（small noncoding RNA，sncRNA），称为PIWI相互作用RNA（PIWI-interacting RNA，piRNA）。最近的研究表明皮尔纳/PIWI通路在动物生殖细胞中转座子的沉默和mRNA的转录后调控中起着关键作用。中国科学院上海生物化学与细胞生物学研究所刘墨芳博士实验室的一项研究揭示了PIWI代谢（小鼠PIWI称为MIWI;人类PIWI称为HIWI）在哺乳动物精子发生中的生理和病理重要性。在这里，我们总结了我们目前对哺乳动物（重点是小鼠和人类）中皮尔纳/PIWI通路的理解，这是精子发生的基本组成部分，确保男性生育力和基因组完整性。
A class of 24-32 nt PIWI-binding small noncoding RNAs (sncRNAs) termed as PIWI-interacting RNAs (piRNAs) have been identified in animal germline. Recent studies suggest that piRNA/PIWI pathway plays a critical role in both silencing of transposons and posttranscriptional regulation of mRNAs in animal germline. A study from Dr. Mofang Liu's lab in Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, reveals the physiological and pathological importance of PIWI metabolism (mouse PIWI as known as MIWI; human PIWI as HIWI) in mammalian spermatogenesis. Here, we summarize our current understanding of the piRNA/PIWI pathway in mammals (focusing on mouse and human), which is emerging as a fundamental component of spermatogenesis that ensures male fertility and genome integrity.