Effect of 3 dentifrices containing triclosan and various additives - An experimental gingivitis study
Effect of 3 dentifrices containing triclosan and various additives - An experimental gingivitis study
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DOI：
10.1034/j.1600-051x.2000.027007494.x
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发表时间：
2000-07-01
影响因子：
6.7
通讯作者：
Cury, JA
中科院分区：
文献类型：
--
作者：
Nogueira, GR;Toledo, S;Cury, JA
背景：采用为期21天的部分口腔牙龈炎实验模型评价3种牙膏的抗牙菌斑和抗牙龈炎效果。方法：25名志愿者参加了这项交叉、双盲研究，分4个阶段进行，每个阶段21天。在研究的每个阶段，为每位志愿者制作了 IV 象限的牙罩。将市场上的 2 种抗牙菌斑洁牙剂（一种含有三氯生 + pvm/ma，另一种含有三氯生 + Zn）与实验配方及其安慰剂进行比较。实验牙膏含有三氯生 + pvm/ma + Zn + PPi，安慰剂（对照）不含这些物质。根据受试者的全口基线牙菌斑 (PI)、牙龈炎 (GI) 和出血 (BI) 指数评分对受试者进行分层，然后随机分配到 4 种牙膏中的一种。在每个阶段，当志愿者用一种洁牙剂刷牙时，第四象限受到装满所用洁牙剂的牙罩的保护。每个阶段后，测定牙菌斑、牙龈炎和出血指数。 结果：结果显示，与对照相比，只有含有三氯生 + pvm/ma + Zn + PPi 的配方能够降低 PI (28.8%)、GI (35.9%) 和 BI (30.4%) (p
Background: The antiplaque and antigingivitis effect of 3 dentifrices was evaluated using the 21-day partial-mouth experimental model of gingivitis.Method: 25 volunteers took part in this cross-over, double-blind study, carried out in 4 phases of 21 days each. For each phase of the study, a toothshield of the IV quadrant was constructed for each volunteer. 2 antiplaque dentifrices from the market, one containing triclosan + pvm/ma and the other triclosan + Zn, were compared with an experimental formulation and its placebo. The experimental dentifrice contained triclosan + pvm/ma + Zn + PPi and the placebo (control) did not contain these substances. The subjects were stratified according to their whole-mouth baseline plaque (PI), gingivitis (GI) and bleeding (BI) index scores, and then randomly assigned to 1 of 4 dentifrices. During each phase, while the volunteers brushed their teeth with one of the dentifrices, the IV quadrant was protected by the toothshield filled with the dentifrice used. After each phase, dental plaque, gingivitis and bleeding indices were determined.Results: The results showed that only the formulation containing triclosan + pvm/ma + Zn + PPi was able to reduce PI (28.8%), GI (35.9%) and BI (30.4%) in comparison with controls (p