An injectable borate bioactive glass cement for bone repair: Preparation, bioactivity and setting mechanism
An injectable borate bioactive glass cement for bone repair: Preparation, bioactivity and setting mechanism
复制标题
用于骨修复的可注射硼酸盐生物活性玻璃水泥：制备、生物活性和凝固机制
DOI：
10.1016/j.jnoncrysol.2015.06.001
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发表时间：
2016-01-15
影响因子：
3.5
通讯作者：
Rahaman, Mohamed N.
中科院分区：
文献类型：
--
作者：
Cui, Xu;Zhang, Yadong;Rahaman, Mohamed N.
需要合成生物材料来使用微创手术重建骨缺损。在这项研究中，制备，生物活性和凝固机制的可注射水泥组成的硼酸盐生物活性玻璃颗粒和壳聚糖溶液进行了评估，作为不同的固液比（SL）的函数。随着SL比率从1.0 g/ml增加到2.5 g/ml，可注射性和初凝时间分别从97 +/- 1%降低到84 +/- 10%和从16.9 +/- 0.9 min降低到3.0 +/- 0.5 min，而水泥的抗压强度从8 +/- 2 MPa增加到31 +/- 2 MPa。水泥在剧烈搅拌的水介质中保持其粘结性。当浸入磷酸盐缓冲盐水中时，玻璃相反应并转化为羟基磷灰石。水泥的固化机制似乎涉及一系列过程的组合，如壳聚糖溶液的溶胶-凝胶转变，转化的玻璃表面和壳聚糖之间形成互锁界面，以及转化的玻璃表面和壳聚糖的官能团之间的键合。通过控制玻璃颗粒和壳聚糖溶液之间的反应，可以产生具有骨修复应用所需的可加工性、降解性、强度和生物活性的可注射水泥。(C)2015爱思唯尔B. V.保留所有权利。
There is a need for synthetic biomaterials to reconstruct bone defects using minimal invasive surgery. In this study, the preparation, bioactivity and setting mechanism of an injectable cement composed of borate bioactive glass particles and a chitosan solution was evaluated as a function of varying solid to liquid (SL) ratio. As the SL ratio increased from 1.0 g/ml to 2.5 g/ml, the injectability and initial setting time decreased from 97 +/- 1% to 84 +/- 10% and from 16.9 +/- 0.9 min to 3.0 +/- 0.5 min, respectively, while the compressive strength of the cement increased from 8 +/- 2 MPa to 31 +/- 2 MPa. The cement maintained its cohesiveness in a vigorously stirred aqueous medium. When immersed in phosphate-buffered saline, the glass phase reacted and converted to hydroxyapatite. The setting mechanism of the cement appeared to involve a combination of processes, such as the sol-gel transition of the chitosan solution, formation of an interlocked interface between the converted glass surface and the chitosan, and bonding between the converted glass surface and the functional groups of the chitosan. By controlling the reaction between the glass particles and the chitosan solution, injectable cements can be created with the requisite workability, degradation, strength and bioactivity for bone repair applications. (C) 2015 Elsevier B.V. All rights reserved.