Cluster-Buster: finding dense clusters of motifs in DNA sequences
Cluster-Buster: finding dense clusters of motifs in DNA sequences
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DOI：
10.1093/nar/gkg540
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发表时间：
2003-07-01
影响因子：
14.9
通讯作者：
Weng, ZP
中科院分区：
文献类型：
--
作者：
Frith, MC;Li, MC;Weng, ZP
决定特定基因对适当刺激的激活和抑制的信号是基因组DNA中编码的最重要但最不了解的信息类型之一。优先被各种转录因子结合的核苷酸序列模式或基序已被收集在数据库中。然而，这些基序似乎是单独太短和退化，使检测功能增强子和沉默元件在一个大的基因组。一些研究小组提出，密集的基序簇可以更准确地诊断调控区。Buster是我们的软件的第三个化身，用于在DNA序列中查找预先指定的基序簇。我们在http://zlab.bu.edu/cluster-buster/上提供一个黑客克星网络服务器。
The signals that determine activation and repression of specific genes in response to appropriate stimuli are one of the most important, but least understood, types of information encoded in genomic DNA. The nucleotide sequence patterns, or motifs, preferentially bound by various transcription factors have been collected in databases. However, these motifs appear to be individually too short and degenerate to enable detection of functional enhancer and silencer elements within a large genome. Several groups have proposed that dense clusters of motifs may diagnose regulatory regions more accurately. Cluster-Buster is the third incarnation of our software for finding clusters of pre-specified motifs in DNA sequences. We offer a Cluster-Buster web server at http://zlab.bu.edu/cluster-buster/.