MORPHOMETRIC ANALYSIS OF BLOOD-VESSELS IN SYNOVIAL MEMBRANES OBTAINED FROM CLINICALLY AFFECTED AND UNAFFECTED KNEE JOINTS OF PATIENTS WITH RHEUMATOID-ARTHRITIS
MORPHOMETRIC ANALYSIS OF BLOOD-VESSELS IN SYNOVIAL MEMBRANES OBTAINED FROM CLINICALLY AFFECTED AND UNAFFECTED KNEE JOINTS OF PATIENTS WITH RHEUMATOID-ARTHRITIS
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DOI：
10.1136/ard.50.11.792
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发表时间：
1991-11-01
影响因子：
27.4
通讯作者：
BRESNIHAN, B
中科院分区：
文献类型：
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作者：
FITZGERALD, O;SODEN, M;BRESNIHAN, B
对13例未经治疗的类风湿关节炎患者的炎症和非炎症膝关节滑膜组织进行了血管增殖和内皮细胞的形态观察。类风湿关节炎患者炎症关节组织和非炎症关节组织血管周围单个核细胞浸润，滑膜衬里增厚；类风湿关节炎患者炎症关节组织血管增生，内皮细胞形态改变，呈高内皮小静脉样改变。这些关于类风湿性关节炎的观察。这些观察结果表明，单个核细胞从外周血向血管周围和衬里层的迁移发生在血管增殖和内皮细胞形态改变之前。
Synovial tissues from inflamed and non-inflamed knee joints of 13 patients with untreated rheumatoid arthritis were examined for vascular proliferation and morphological alteration of endothelial cells. Perivascular mononuclear cell infiltration and increased thickness of the synovial lining layer were noted in tissues from inflamed and non-inflamed joints of patients with rheumatoid arthritis; vascular proliferation and morphological alteration of endothelial cells to resemble high endothelial venules were seen only in tissues from inflamed joints of patients with rheumatoid arthritis. These observations with rheumatoid arthritis. These observations suggest that the migration of mononuclear cells from the peripheral blood to the perivascular areas and lining layer occurs before vascular proliferation and morphological alteration of endothelial cells.