Involvement of δ-opioid receptors in the effects of morphine on locomotor activity and the mesolimbic dopaminergic system in mice
Involvement of δ-opioid receptors in the effects of morphine on locomotor activity and the mesolimbic dopaminergic system in mice
复制标题
δ-阿片受体参与吗啡对小鼠运动活动和中脑边缘多巴胺能系统的影响
作者：
M. Narita;Tsutomu Suzuki;M. Funada;M. Misawa;H. Nagase
Naltrindole （NTI）和ntrtriben （NTB）是NTI的苯并呋喃衍生物，是近年来合成的高选择性δ-阿片受体拮抗剂。NTI和NTB均不能抑制吗啡诱导的抗伤害感受作用。相比之下，NTI和NTB均能显著抑制吗啡诱导的小鼠边缘前脑过度运动和多巴胺（DA）周转量的增加。这些结果表明，δ-阿片受体至少在吗啡诱导的中边缘DA系统的过度运动和兴奋中起部分作用，但不是抗感觉。
Naltrindole (NTI) and naltriben (NTB), a benzofuran derivative of NTI, were recently synthesized as highly selective δ-opioid receptor antagonists. Both NTI and NTB failed to suppress the antinociceptive effect induced by morphine. In contrast, both NTI and NTB significantly suppressed the morphine-induced hyperlocomotion and increase in turnover of dopamine (DA) in the mouse limbic forebrain. These results suggest that δ-opioid receptors play, at least in part, a role in the morphine-induced hyperlocomotion and excitation of mesolimbic DA systems, but not antinociception.
Mu 阿片受体参与腹侧被盖区多巴胺神经元的脑啡肽激活。
DOI：
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发表时间：
1987
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
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作者：
Latimer,LG;Duffy,P;Kalivas,PW
通讯作者：
Kalivas,PW