Potential Inhibitory Effects of L-Carnitine Supplementation on Tissue Advanced Glycation End Products in Patients with Hemodialysis
Potential Inhibitory Effects of L-Carnitine Supplementation on Tissue Advanced Glycation End Products in Patients with Hemodialysis
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DOI：
10.1089/rej.2013.1459
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发表时间：
2013-12-01
影响因子：
2.6
通讯作者：
Okuda, Seiya
中科院分区：
文献类型：
--
作者：
Fukami, Kei;Yamagishi, Sho-ichi;Okuda, Seiya
背景和目的：晚期糖基化终末产物 (AGE) 会导致血液透析 (HD) 患者发生心血管疾病。我们最近发现 HD 患者的肉碱水平与皮肤 AGE 水平呈负相关。我们检查了左旋肉碱补充剂是否降低了肉碱缺乏的 HD 患者的皮肤 AGE 水平。方法：这是一项单中心研究。 102 名 HD 患者（总肉碱水平
Background and Aims: Advanced glycation end products (AGEs) contribute to cardiovascular disease in patients with hemodialysis (HD). We have recently found that carnitine levels are inversely associated with skin AGE levels in HD patients. We examined whether l-carnitine supplementation reduced skin AGE levels in HD patients with carnitine deficiency. Methods: This was a single-center study. One hundred and two HD patients (total carnitine levels