Synchronization between embryo development and endometrium is a contributing factor for rescue ICSI outcome
Synchronization between embryo development and endometrium is a contributing factor for rescue ICSI outcome
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胚胎发育和子宫内膜之间的同步是挽救 ICSI 结果的一个因素
DOI：
10.1016/j.rbmo.2012.02.001
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发表时间：
2012-05-01
影响因子：
4
通讯作者：
Wu Yuqi
中科院分区：
文献类型：
--
作者：
Li Ming;Liu Ping;Wu Yuqi
最近的证据表明，由于临床妊娠率低，补救性卵胞浆内单精子注射（ICSI）的结果并不令人满意。这些结果可能是由于ICSI前培养的卵母细胞的体外老化或胚胎发育阶段和子宫内膜分泌模式之间的差异。为了解决后一个问题，本研究对534个补救ICSI后的新鲜周期和64个后续治疗中的冻融周期进行了回顾性分析。救援ICSI周期分为三组：I组包括469个新鲜胚胎移植（FET）周期; II组包括74个FET周期，其中额外的优质胚胎也被冷冻保存; III组包括64个冻融移植周期。第三组被认为比第二组实现了更好的同步。结果显示，Ⅲ组临床妊娠率（29.69%，19/64）和种植率（13.33%，22/165）均显著高于Ⅱ组（10.81%，8/74）和种植率（5.13%，8/156）（P均< 0.05）。因此，胚胎发育与子宫内膜同步被认为是补救性ICSI结局的一个影响因素。建议将来自补救ICSI周期的胚胎冷冻保存，随后用于冻融周期。(C)2012年，爱思唯尔有限公司出版的生殖保健有限公司。版权所有。
Recent evidence shows that the outcome of rescue intracytoplasmic sperm injection (ICSI) is unsatisfactory on account of a poor clinical pregnancy rate. These outcomes may be due to either the in-vitro ageing of cultured oocytes before ICSI or the asynchrony between the embryo developmental stage and the endometrial secretory pattern. To address the latter issue, this study performed a retrospective analysis of 534 fresh cycles after rescue ICSI and 64 frozen-thawed cycles in subsequent treatment. Rescue ICSI cycles were divided into three groups: group I included 469 fresh embryo-transfer (FET) cycles; group II included 74 FET cycles in which supernumerary good-quality embryos were also cryopreserved; and group III included 64 frozen-thawed transfer cycles. Group III was considered to have achieved better synchronization than group II. As a result, significantly higher clinical pregnancy (29.69%, 19/64 versus 10.81%, 8/74) and implantation (13.33%, 22/165 versus 5.13%, 8/156) rates were achieved in group III compared with group II (both P < 0.05). Therefore, synchronization of embryo development with the endometrium is considered a contributing factor for rescue ICSI outcome. It is recommended that embryos derived from rescue ICSI cycles should be cryopreserved and subsequently used in frozen-thawed cycles. (C) 2012, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.