The FAS Screen: a rapid screening tool for fetal alcohol syndrome
The FAS Screen: a rapid screening tool for fetal alcohol syndrome
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DOI：
10.1080/13556219971542
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发表时间：
1999-07-01
影响因子：
3.4
通讯作者：
Klug, MG
中科院分区：
文献类型：
--
作者：
Burd, L;Cox, C;Klug, MG
胎儿酒精综合征是导致智力低下和发育障碍的重要原因。基于人群的筛查工具将允许早期诊断和进入干预方案。该研究的目的是开发一种用于基于人群的设置，以提高识别FAS的儿童简短的筛选工具。在六个研究中心开发并测试了FAS筛查。这些都是为儿童服务的网站，都位于北达科他州。对1013名儿童进行了筛查，发现65名儿童的筛查评分为阳性，并被转介进行进一步调查。40人接受了医学遗传学家的评估，6人被诊断为FAS。筛查工具的估计值为：特异性94.1%，灵敏度100%，阳性预测值9.1%和阴性预测值100%。筛查费用为每个儿童13.00美元，每个确诊病例的费用为4，100美元。FAS筛选是一种简单的筛选测试，具有可接受的性能特征，具有成本效益。
Fetal alcohol syndrome (FAS) is an important cause of mental retardation and developmental disabilities. A population based screening tool would allow for early diagnosis and entry into intervention programs. The aim of the study was to develop a brief screening tool for use in population-based settings to improve the identification of children with FAS. The FAS Screen was developed and tested in six sites. These were sites that served children and all were located in North Dakota. Screening was completed on 1013 children, 65 were found to have a positive screening score and were referred for further investigation. Forty were seen for evaluation by a medical geneticist and six were diagnosed with FAS. The estimated values for the screening tool were: specificity 94.1%, sensitivity 100%, positive predictive value 9.1% and negative predictive value 100%. The cost of screening was $13.00 per child and the cost per case identified was $4,100. The FAS Screen is a brief screening test with acceptable performance characteristics and is cost effective.