Additive interactions of maternal prepregnancy BMI and breast-feeding on childhood overweight
Additive interactions of maternal prepregnancy BMI and breast-feeding on childhood overweight
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DOI：
10.1038/oby.2005.48
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发表时间：
2005-02-01
期刊：
影响因子：
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通讯作者：
Ahluwalia, JS
中科院分区：
文献类型：
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作者：
Li, CY;Kaur, H;Ahluwalia, JS
目的：为了研究母亲孕前体重指数和母乳喂养的儿童超重的风险2至14岁age.Research方法和程序的相互作用：1996年全国纵向调查的青年，儿童和年轻的成年人在美国的数据进行了分析（n = 2636）。加权样本代表51.3%的男孩，78.0%的白人，15.0%的黑人和7.0%的西班牙裔。儿童期超重定义为BMI >=年龄和性别的第95百分位数。孕妇孕前肥胖的标准为BMI >= 30 kg/m2。母乳喂养的持续时间测量为从出生到母乳喂养结束的周数。结果：在调整潜在的混杂因素后，母亲在怀孕前肥胖的儿童比母亲BMI正常的儿童有更大的超重风险[调整后的比值比（OR），4.1; 95%置信区间（CI），2.6，6.4（< 25 kg/m2;线性趋势P < 0.001）。母乳喂养4个月与儿童期超重风险较低相关（OR，0.6; 95%CI，0.4，1.0;线性趋势p = 0.06）。母亲孕前肥胖与缺乏母乳喂养之间存在加性交互作用（p < 0.05），因此母亲肥胖且从未接受母乳喂养的儿童超重的风险最大（OR，6.1; 95% CI，2.9，13.1）。母亲孕前肥胖和缺乏母乳喂养的结合可能与儿童超重的风险更大有关。在制定儿童肥胖干预计划时，可能需要特别关注肥胖母亲和缺乏母乳喂养的儿童。
Objective: To examine the interactions of maternal prepregnancy BMI and breast-feeding on the risk of overweight among children 2 to 14 years of age.Research Methods and Procedures: The 1996 National Longitudinal Survey of Youth, Child and Young Adult data in the United States were analyzed (n = 2636). The weighted sample represented 51.3% boys, 78.0% whites, 15.0% blacks, and 7.0% Hispanics. Childhood overweight was defined as BMI >= 95th percentile for age and sex. Maternal prepregnancy obesity was determined as BMI >= 30 kg/m(2). The duration of breast-feeding was measured as the weeks of age from birth when breast-feeding ended.Results: After adjusting for potential confounders, children whose mothers were obese before pregnancy were at a greater risk of becoming overweight [adjusted odds ratio (OR), 4.1; 95% confidence interval (CI), 2.6, 6.4] than children whose mothers had normal BMI (< 25 kg/m(2); P < 0.001 for linear trend). Breast-feeding for 4 months was associated with a lower risk of childhood overweight (OR, 0.6; 95% CI, 0.4, 1.0; p = 0.06 for linear trend). The additive interaction between maternal prepregnancy obesity and lack of breast-feeding was detected (p < 0.05), such that children whose mothers were obese and who were never breast-fed had the greatest risk of becoming overweight (OR, 6.1; 95% CI, 2.9, 13.1).Discussion: The combination of maternal prepregnancy obesity and lack of breast-feeding may be associated with a greater risk of childhood overweight. Special attention may be needed for children with obese mothers and lack of breast-feeding in developing childhood obesity intervention programs.