Effect of chronic ethanol consumption on aldehyde dehydrogenase activity in the baboon.
Effect of chronic ethanol consumption on aldehyde dehydrogenase activity in the baboon.
复制标题
长期乙醇消耗对狒狒醛脱氢酶活性的影响。
DOI：
10.1016/0006-2952(81)90098-8
复制
发表时间：
1981
影响因子：
5.8
通讯作者：
Lieber,CS
中科院分区：
文献类型：
--
作者：
Lebsack,ME;Gordon,ER;Lieber,CS
狒狒肝脏的线粒体、微粒体和可溶性部分具有可检测到的醛脱氢酶（A1DH）活性。根据动力学数据，线粒体和可溶性部分似乎都含有两种形式的A1DH，一种是高的，另一种是低的，对于乙醛。在微粒体中，只有毫摩尔浓度的乙醛才有活性。在狒狒的肝脏中，大约75%的A1DH活性存在于线粒体中，20%存在于可溶性部分。慢性乙醇消耗降低了狒狒肝脏中总线粒体和低线粒体A1DH活性。在大鼠中，乙醇消耗也导致线粒体lowKmA1DH活性降低。
Baboon liver has detectable aldehyde dehydrogenase (A1DH) activity in the mitochondrial, microsomal and soluble fractions. Based on kinetic data, the mitochondrial and soluble fractions each appear to contain two forms of A1DH, one with a high, and another with a low,Kmfor acetaldehyde. In the microsomes there was activity only with millimolar concentrations of acetaldehyde. In the baboon liver, about 75 per cent of total A1DH activity resides in the mitochondria and 20 per cent in the soluble faction. Chronic ethanol consumption decreased total and lowKmmitochondrial A1DH activity in baboon liver. In rats, ethanol consumption also resulted in decreased mitochondrial lowKmA1DH activity.