The role of capsule on the performance of a dry powder inhaler using computational and experimental analyses
The role of capsule on the performance of a dry powder inhaler using computational and experimental analyses
复制标题
DOI：
10.1007/s11095-005-4587-y
复制
发表时间：
2005-06-01
影响因子：
3.7
通讯作者：
Raper, JA
中科院分区：
文献类型：
--
作者：
Coates, MS;Fletcher, DF;Raper, JA
目的。研究旋转胶囊对干粉吸入器（Aerolizer， R）整体性能的基本影响。胶囊运动是用高速摄影可视化的。通过计算流体动力学（CFD）分析，确定了在60 l min（-1）时不同尺寸胶囊存在和不存在时装置内产生的流场。在相同流量下，采用多级液体冲击器对甘露醇粉末吸入器的分散性能进行了测试。发现胶囊尺寸（3、4和5）对装置流场、颗粒-装置撞击频率或吸入器的分散性能没有显著差异。减小胶囊大小只减少了4%的胶囊滞留。相比之下，没有旋转胶囊的存在，湍流水平增加了65%，FPFEm （wt%颗粒）
Purpose. To study the fundamental effects of the spinning capsule on the overall performance of a dry powder inhaler (Aerolizer(R)).Methods. The capsule motion was visualized using high-speed photography. Computational fluid dynamics (CFD) analysis was performed to determine the flowfield generated in the device with and without the presence of different sized capsules at 60 l min(-1). The inhaler dispersion performance was measured with mannitol powder using a multistage liquid impinger at the same flowrate.Results. The capsule size (3, 4, and 5) was found to make no significant difference to the device flowfield, the particle-device impaction frequency, or the dispersion performance of the inhaler. Reducing the capsule size reduced only the capsule retention by 4%. In contrast, without the presence of the spinning capsule, turbulence levels were increased by 65%, FPFEm (wt% particles