Reliability, validity and responsiveness to change of the Patient Report of Extent of Psoriasis Involvement (PREPI) for measuring body surface area affected by psoriasis
Reliability, validity and responsiveness to change of the Patient Report of Extent of Psoriasis Involvement (PREPI) for measuring body surface area affected by psoriasis
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DOI：
10.1111/j.1365-2133.2009.09589.x
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发表时间：
2010-04-01
影响因子：
10.3
通讯作者：
Gelfand, J. M.
中科院分区：
文献类型：
--
作者：
Dommasch, E. D.;Shin, D. B.;Gelfand, J. M.
研究背景发展一种简单、可靠、有效和反应灵敏的方法来测量银屑病患者皮肤受累的程度，对于流行病学研究具有重要意义。测量受银屑病影响的体表面积的单一问题方法方法这是对140名银屑病患者的横断面研究，具有探索性前瞻性纵向队列组成部分。通过一个测试，重测的方法和标准效度进行了研究，通过比较PREPI与皮肤科医生参与的体表面积的评估。我们还将Skindex-29评分与PREPI进行了比较。为了证明反应性和建立PREPI中最小的重要差异，我们创建了PREPI仪器的受试者工作特征曲线。结果PREPI的重测信度接近完美[组内相关系数（ICC）= 0中心点99，95%置信区间（CI）0中心点97-0中心点99]，患者和医生的评估基本一致（ICC = 0中心点82，95%CI 0中心点75-0中心点87）。PREPI与所有Skindex-29域均显示出显著相关性。我们发现的PREPI是响应变化和确定的PREPI评分的变化，有很好的区分患者和没有一个最低限度的重要的临床differentiation.ConclusionsOur研究表明，PREPI是一个可靠的，有效的和响应措施的体表面积受银屑病的影响，可能是有用的，为未来的流行病学研究。
P>BackgroundThe development of a simple, reliable, valid and responsive method for measuring the extent of skin involvement in psoriasis is important for use in epidemiological studies.ObjectivesWe sought to investigate the psychometric characteristics of the Patient Report of Extent of Psoriasis Involvement (PREPI), a single-question method for measuring body surface area affected by psoriasis.MethodsThis was a cross-sectional study of 140 patients with psoriasis, with an exploratory prospective longitudinal cohort component. Reliability was measured via a test-retest approach and criterion validity was investigated by comparing the PREPI with an assessment of body surface area of involvement by a dermatologist. We additionally compared Skindex-29 scores with the PREPI. To demonstrate responsiveness and establish a minimally important difference in the PREPI, we created receiver operating characteristic curves for the PREPI instrument.ResultsThe test-retest reliability of the PREPI was nearly perfect [intraclass correlation coefficient (ICC) = 0 center dot 99, 95% confidence interval (CI) 0 center dot 97-0 center dot 99], and there was substantial agreement between patient and physician assessments (ICC = 0 center dot 82, 95% CI 0 center dot 75-0 center dot 87). The PREPI showed significant correlations with all Skindex-29 domains. We found the PREPI to be responsive to change and identified changes in the PREPI score that have good discrimination between patients with and without a minimally important clinical difference.ConclusionsOur study suggests that the PREPI is a reliable, valid and responsive measure of body surface area affected by psoriasis that may be useful for future epidemiological research.