Multidimensional analysis of clinicopathological characteristics of false-negative clinically significant prostate cancers on multiparametric MRI of the prostate in Japanese men.
Multidimensional analysis of clinicopathological characteristics of false-negative clinically significant prostate cancers on multiparametric MRI of the prostate in Japanese men.
复制标题
日本男性前列腺多参数 MRI 假阴性临床显着前列腺癌的临床病理特征的多维分析。
DOI：
10.1007/s11604-018-0801-9
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发表时间：
2019
期刊：
影响因子：
2.1
通讯作者：
Sone T.
中科院分区：
文献类型：
--
作者：
Kido A;Tamada T;Kanomata N;Yamamoto A;Miyaji Y;Nagai A;Sone T.
目的探讨多参数前列腺MRI（mpMRI）假阴性的临床意义前列腺癌（csPC）的临床病理特征。两名放射科医生使用PI-RADS v2独立评价mpMR图像。比较（a）使用总体mpMRI标准（o-mpMRI标准）可检测和不可检测的病灶（o-mpMRI标准）和（B）在DCE-MRI上具有早期增强效应（ERF）的病灶和没有ERF的病灶之间的临床病理结果。在38个小于PI-RADS v2 3类的假阴性病变中，DCE-MRI检测到14个病变。与118个可检测病灶相比，17个o-mpMR标准未检测病灶的PSA和D 'amico风险分类较低，肿瘤表观扩散系数（ADC）较高（p≤ 0.048）。89个病灶的PSA、肿瘤大小、肿瘤切除术GS分级、GS ≥ 4 + 3的病灶频率均高于38个病灶（p≤ 0.046）。此外，o-mpMRI标准上的假阴性病变的特征在于尺寸小、风险低和细胞密度低。
PurposeTo clarify clinicopathological features of false-negative clinically significant prostate cancer (csPC) at multiparametric prostate MRI (mpMRI).Methods95 patients with 139 csPC undergoing 3T mpMRI before radical prostatectomy were included. Two radiologists were independently evaluated mpMR images using PI-RADS v2. Clinicopathological findings were compared between (a) detectable and undetectable lesions using overall mpMRI criteria (o-mpMRI criteria) and (b) lesions with early enhancement effect (EEE) and lesions without EEE at DCE-MRI.ResultsThe detection rate of csPS using cutoff value of category 3 or more in PI-RADS v2 for positive lesion was 72.1% (98/136 lesions). In 38 false-negative lesions with less than PI-RADS v2 category 3, the DCE-MRI detected 14 lesions. 17 undetectable lesions on o-mpMR criteria had lower PSA and D’amico risk classification, and higher tumor apparent diffusion coefficient (ADC) than those of 118 detectable lesions (p≤ 0.048). 89 lesions with EEE showed higher PSA, tumor size, prostatectomy GS grade, frequency of lesions with GS ≥ 4 + 3 and lower tumor ADC than those in 38 lesions without EEE (p≤ 0.046).ConclusionTumor detectability of csPC with PI-RADS v2 was limited compared with o-mpMRI criteria in Japanese men. Moreover, false-negative lesions on o-mpMRI criteria were characterized as small in size, low risk and low cellularity.