Oxidative Stress and Autophagy
Oxidative Stress and Autophagy
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DOI：
10.1007/978-981-15-0602-4_9
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发表时间：
2019-01-01
期刊：
影响因子：
--
通讯作者：
Gao, Qi
中科院分区：
文献类型：
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作者：
Gao, Qi
人类生活在一个复杂的环境中，总是面临着各种外部刺激和内部变化，包括氧化应激和组织损伤。为了适应这些刺激，维持生理稳定性，并确保生存，体内的细胞启动了一系列相互作用和调节的反应通路。例如，体内活性氧物种的增加可以通过各种信号通路诱导自噬。本部分将重点介绍ROS通过PI3K/Akt、AMPK、JNK、ERK、ATG4等途径对自噬的调节。
Living in a complex environment, humans are always faced with various external stimuli and internal changes including oxidative stress and tissue damage. To adapt to these stimuli, maintain physiological stability, and ensure survival, cells in the body initiate a series of interactive and regulatory response pathways. For example, increased reactive oxygen species in the body can induce autophagy through a variety of signalling pathways. This section will focus on ROS-mediated regulation of autophagy through PI3K/Akt, AMPK, JNK, ERK, ATG4, and other pathways.