POINT-SOURCE NERVE BUNDLE STIMULATION - EFFECTS OF FIBER DIAMETER AND DEPTH ON SIMULATED EXCITATION
POINT-SOURCE NERVE BUNDLE STIMULATION - EFFECTS OF FIBER DIAMETER AND DEPTH ON SIMULATED EXCITATION
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DOI：
10.1109/10.55679
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发表时间：
1990-07-01
影响因子：
4.6
通讯作者：
PLONSEY, R
中科院分区：
文献类型：
--
作者：
ALTMAN, KW;PLONSEY, R
分析评估位于圆柱形神经束内不同深度的不同直径有髓神经纤维对点源电极施加场的激发响应。对于势场计算，纤维束被认为浸没在无限各向同性导电介质中，并被理想化为无限延伸的圆柱体，表示为各向异性双域（其中包括从间隙到细胞内空间的电耦合）。有髓神经纤维的兴奋是根据核心传导神经模型确定的，其节点电流由弗兰肯霍斯-赫胥黎动力学和上述提供施加电位的场描述。神经纤维达到阈值所需的刺激水平响应于体积导体的四种描述而被量化：各向同性均匀情况、单域情况、双域情况和修改的单域情况。模型结果表明了神经束双域表示的重要性，并提供了对物理介质与神经纤维兴奋生理特性之间关系的深入了解。<>
Excitation response of different diameter myelinated nerve fibers situated at various depths within a cylindrical nerve bundle from the applied field of a point source electrode are analytically evaluated. For the potential field calculation, the fiber bundle is considered to be immersed in an infinite isotropic conductive medium and is idealized as an infinitely extending cylinder represented as an anisotropic bidomain (where electrical coupling from interstitial to intracellular space is included). Myelinated nerve fiber excitation is determined from a core-conductive nerve model, whose nodal currents are described by the Frankenhaeuser-Huxley kinetics and the aforementioned field providing the applied potentials. The stimulation level necessary for a nerve fiber to reach threshold is quantified in response to four descriptions of the volume conductor: the isotropic homogeneous case, the monodomain case, the bidomain case, and the modified monodomain case. Model results indicate the importance of a bidomain representation of the nerve bundle and provide insight into the relationship between the physical medium and the physiological properties of nerve fiber excitation.<>