High-density-lipoprotein metabolism during a very-low-calorie diet.
High-density-lipoprotein metabolism during a very-low-calorie diet.
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极低热量饮食期间的高密度脂蛋白代谢。
DOI：
10.1093/ajcn/56.1.297s
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发表时间：
1992
影响因子：
7.1
通讯作者：
Hirotoshi Morii
中科院分区：
文献类型：
--
作者：
T. Shoji;Yoshiki Nishizawa;Hidenori Koyama;Satoshi Hagiwara;H. Aratani;Kyoko Sasao;Hiroshi Kishimoto;H. Tanishita;Hirotoshi Morii
我们研究了8名女性肥胖患者接受极低热量饮食（VLCD）后高密度脂蛋白（HDL）代谢的变化。在研究的前半部分，HDL胆固醇（HDL-C）、载脂蛋白A-I（apo A-I）和apo A-II显示出平行降低。虽然脂蛋白脂肪酶（LPL）和肝脂肪酶（HTGL）没有变化，卵磷脂：胆固醇酰基转移酶（LCAT）下降。在方案的后半部分，HDL-C和apo A-I升高，而apo A-II降低，导致apo A-I-A-II比值升高。LPL、HTGL或LCAT无变化。LCAT和载脂蛋白组成可能是VLCD后HDL-C变化的重要因素。
We examined the changes in high-density-lipoprotein (HDL) metabolism in eight female obese patients undergoing a very-low-calorie diet (VLCD). In the first half of the study, HDL cholesterol (HDL-C), apolipoprotein A-I (apo A-I), and apo A-II showed a parallel decrease. Although lipoprotein lipase (LPL) and hepatic lipase (HTGL) did not change, lecithin: cholesterol acyltransferase (LCAT) decreased. In the latter half of the protocol, HDL-C and apo A-I increased whereas apo A-II decreased, resulting in increased apo A-I-A-II ratios. There was no change in LPL, HTGL, or LCAT. LCAT and apolipoprotein composition may be important in HDL-C changes after VLCD.