Plant- and marine-derived n-3 polyunsaturated fatty acids have differential effects on fasting and postprandial blood lipid concentrations and on the susceptibility of LDL to oxidative modification in moderately hyperlipidemic subjects
Plant- and marine-derived n-3 polyunsaturated fatty acids have differential effects on fasting and postprandial blood lipid concentrations and on the susceptibility of LDL to oxidative modification in moderately hyperlipidemic subjects
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DOI：
10.1093/ajcn/77.4.783
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发表时间：
2003-04-01
影响因子：
7.1
通讯作者：
Williams, CM
中科院分区：
文献类型：
--
作者：
Finnegan, YE;Minihane, AM;Williams, CM
背景：人类饮食中的a-亚麻酸（ALA）可以转化为长链n-3多不饱和脂肪酸（PUFAs），并可能复制二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）对心血管疾病危险因素的一些有益作用。目的：本研究旨在比较饮食中ALA和EPA+DHA摄入量增加对一系列动脉粥样硬化危险因素的影响。设计：这是一项安慰剂对照的平行研究，涉及150名中度高脂血症受试者，随机分配到5种干预措施中的一种：0.8或1.7 g EPA+DHA/d， 4.5或9.5 g ALA/d，或n-6 PUFA对照组，持续6个月。脂肪酸被掺入25 g脂肪涂抹剂和3粒胶囊中，每天食用。结果：与n-6 PUFA对照组相比，在任何n-3 PUFA干预后，空腹或餐后脂质、葡萄糖或胰岛素浓度或血压的变化均无显著差异。1.7 g/d EPA+DHA干预后空腹甘油三酯的平均值（+/- sem）变化（-7.7 +/- 4.99%）与9.5 g/d ALA干预后的平均值（10.9 +/- 4.5%）差异显著（P < 0.05）。1.7 g/d EPA+DHA干预组LDL体外氧化敏感性高于对照组和ALA干预组（P < 0.05）。在任何组中，血浆a-生育酚浓度或全血浆抗氧化状态均无显著变化。结论：在估计的生物等效摄入量下，膳食ALA和EPA+DHA具有不同的生理效应。
Background: Dietary a-linolenic acid (ALA) can be converted to long-chain n-3 polyunsaturated fatty acids (PUFAs) in humans and may reproduce some of the beneficial effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on cardiovascular disease risk factors.Objective: This study aimed to compare the effects of increased dietary intakes of ALA and EPA+DHA on a range of atherogenic risk factors.Design: This was a placebo-controlled, parallel study involving 150 moderately hyperlipidemic subjects randomly assigned to 1 of 5 interventions: 0.8 or 1.7 g EPA+DHA/d, 4.5 or 9.5 g ALA/d, or an n-6 PUFA control for 6 mo. Fatty acids were incorporated into 25 g of fat spread and 3 capsules to be consumed daily.Results: The change in fasting or postprandial lipid, glucose, or insulin concentrations or in blood pressure was not significantly different after any of the n-3 PUFA interventions compared with the n-6 PUFA control. The mean (+/-SEM) change in fasting triacylglycerols after the 1.7-g/d EPA+DHA intervention (-7.7 +/- 4.99%) was significantly (P < 0.05) different from the change after the 9.5-g/d ALA intervention (10.9 +/- 4.5%). The ex vivo susceptibility of LDL to oxidation was higher after the 1.7-g/d EPA+DHA intervention than after the control and ALA interventions (P < 0.05). There was no significant change in plasma a-tocopherol concentrations or in whole plasma antioxidant status in any of the groups.Conclusion: At estimated biologically equivalent intakes, dietary ALA and EPA+DHA have different physiologic effects.