TREM and TREM-like receptors in inflammation and disease.
TREM and TREM-like receptors in inflammation and disease.
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DOI：
10.1016/j.coi.2009.01.009
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发表时间：
2009-02
影响因子：
7
通讯作者：
McVicar DW
中科院分区：
文献类型：
--
作者：
Ford JW;McVicar DW
自从2000年发现触发髓系细胞(TREM)-1表达的受体以来，证明TREM和TREM样受体调节炎症的深刻能力的证据迅速积累。单核细胞、巨噬细胞、髓系树突状细胞、浆细胞样树突状细胞、中性粒细胞、小胶质细胞、破骨细胞和血小板都表达至少一个TREM家族成员，强调了这些蛋白在调节先天抵抗中的重要性。最近关于TREM家族的工作包括：鉴定表达在浆细胞样树突状细胞上的新受体；确定TREM在炎症性肠病和多发性硬化症中的关键作用；与可溶性形式的TREM蛋白释放相关的疾病的扩展列表；以及鉴定第一个具有良好特性的TREM配体：B7-H3，TREM样转录本(TLT)-2的配体。此外，对TREM信号的分析现在已经确定了关键的调控成分，并确定了可能导致TREM和Toll样受体之间复杂功能相互作用的途径。此外，有越来越多的证据表明，Trem通过丛状蛋白-A1调节整合素功能。总而言之，这些新发现将TREM和TREM样受体定义为通过整合炎症信号和与白细胞黏附相关的信号来治疗疾病的多功能调节剂。
Since the discovery of triggering receptor expressed on myeloid cells (TREM)-1 in 2000, evidence documenting the profound ability of the TREM and TREM-like receptors to regulate inflammation has rapidly accumulated. Monocytes, macrophages, myeloid dendritic cells, plasmacytoid dendritic cells, neutrophils, microglia, osteoclasts and platelets all express at least one member of the TREM family, underscoring the importance of these proteins in the regulation of innate resistance. Recent work on the TREM family includes: characterization of a new receptor expressed on plasmacytoid dendritic cells; definition of a key role for TREM in inflammatory bowel disease and multiple sclerosis; an expanded list of diseases associated with the release of soluble forms of TREM proteins; and identification of the first well characterized TREM ligand: B7-H3, a ligand for TREM-like Transcript (TLT)-2. Moreover, analysis of TREM signaling has now identified key regulatory components and defined pathways that may be responsible for the complex functional interactions between the TREM and toll-like receptors. In addition, there is expanding evidence of a role for TREM in the regulation of integrin function via Plexin-A1. Together these new findings define the TREM and TREM-like receptors as pluripotent modifiers of disease through the integration of inflammatory signals with those associated with leukocyte adhesion.
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影响因子：
15.3
作者：
Gibot, S;Kolopp-Sarda, MN;Béné, MC;Bollaert, PE;Lozniewski, A;Mory, F;Levy, B;Faure, GC
通讯作者：
Faure, GC
影响因子：
4.4
作者：
Knapp, S;Gibot, S;van der Poll, T
通讯作者：
van der Poll, T
影响因子：
4.4
作者：
El Mezayen, Rabab;El Gazzar, Mohamed;Nicolls, Mark R.
通讯作者：
Nicolls, Mark R.
影响因子：
4.4
作者：
Hamerman, Jessica A.;Jarjoura, Vessica R.;Lanier, Lewis L.
通讯作者：
Lanier, Lewis L.
影响因子：
4.4
作者：
Daws, MR;Sullam, PM;Seaman, WE
通讯作者：
Seaman, WE