DECREASE OF GLUTATHIONE AND INDUCTION OF GAMMA-GLUTAMYLTRANSFERASE BY DIBUTYRYL-3', 5'-CYCLIC AMP IN RAT-LIVER
DECREASE OF GLUTATHIONE AND INDUCTION OF GAMMA-GLUTAMYLTRANSFERASE BY DIBUTYRYL-3', 5'-CYCLIC AMP IN RAT-LIVER
复制标题
DOI：
10.1016/0006-291x(76)90335-1
复制
发表时间：
1976-01-01
影响因子：
3.1
通讯作者：
SAKAMOTO, Y
中科院分区：
文献类型：
--
作者：
HIGASHI, T;TATEISHI, N;SAKAMOTO, Y
对大鼠给予二丁酰-3 '，5'-环磷酸腺苷会导致肝脏谷胱甘肽明显但暂时的减少。这种降低似乎是由γ-谷氨酰转移酶催化的，因为它伴随着酶的诱导和肝脏中半胱氨酸的增加而发生。肝γ-谷氨酰转移酶的生物半衰期估计约为3小时。推测肝脏中谷胱甘肽和γ-谷氨酰转移酶的生理水平受3′，5 ′-环腺苷酸的控制，肝脏谷胱甘肽可能是半胱氨酸的储存库，半胱氨酸可被γ-谷氨酰转移酶动员。
Administration of dibutyryl-3′,5′-cyclic AMP to rats caused marked, but temporary, decrease of liver glutathione. This decrease appeared to be catalyzed by γ-glutamyltransferase, because it occured concomitantly with induction of the enzyme and increase of cysteine in the liver. The biological half-life of hepatic γ-glutamyltransferase was estimated to be about 3 hours. It is proposed that the physiological levels of glutathione and γ-glutamyltransferase in the liver are controlled by 3′,5′-cyclic AMP, and that liver glutathione may serve as a reservoir of cysteine, which can be mobilized by the transferase.