Risk factors for death from invasive pneumococcal disease, Europe, 2010.
Risk factors for death from invasive pneumococcal disease, Europe, 2010.
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DOI：
10.3201/eid2103.140634
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发表时间：
2015-03
影响因子：
11.8
通讯作者：
Invasive Pneumococcal Disease Study Group
中科院分区：
文献类型：
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作者：
Navarro-Torné A;Dias JG;Hruba F;Lopalco PL;Pastore-Celentano L;Gauci AJ;Invasive Pneumococcal Disease Study Group
风险因肺炎链球菌血清型而异。我们研究了2010年17个欧洲国家报告的侵袭性肺炎球菌疾病病例中患者年龄和性别、临床表现、肺炎链球菌血清型、抗菌素耐药性和死亡之间的可能关联。研究样本包括2，921名患者，其中56.8%为男性，38.2%年龄>65岁。脑膜炎发生率为18.5%。264例（9.0%）病例报告死亡。年龄较大、脑膜炎和对青霉素不敏感与死亡显著相关。5岁以下儿童中的非肺炎球菌结合疫苗（PCV）血清型和5-64岁人群中的7价PCV血清型与死亡风险增加相关;在>65岁的成人中，风险没有血清型的差异。这些发现突出了血清型和年龄之间病死率的差异;因此，在所有年龄段进行持续的流行病学监测对于监测PCV的长期影响至关重要。
Risk varies by Streptococcus pneumoniae serotype. We studied the possible association between patient age and sex, clinical presentation, Streptococcus pneumoniae serotype, antimicrobial resistance, and death in invasive pneumococcal disease cases reported by 17 European countries during 2010. The study sample comprised 2,921 patients, of whom 56.8% were men and 38.2% were >65 years of age. Meningitis occurred in 18.5% of cases. Death was reported in 264 (9.0%) cases. Older age, meningitis, and nonsusceptibility to penicillin were significantly associated with death. Non–pneumococcal conjugate vaccine (PCV) serotypes among children <5 years of age and 7-valent PCV serotypes among persons 5–64 years of age were associated with increased risk for death; among adults >65 years of age, risk did not differ by serotype. These findings highlight differences in case-fatality rates between serotypes and age; thus, continued epidemiologic surveillance across all ages is crucial to monitor the long-term effects of PCVs.