Percutaneous arterial embolization and chemoembolization for treatment of benign and malignant tumors in three dogs and a goat
Percutaneous arterial embolization and chemoembolization for treatment of benign and malignant tumors in three dogs and a goat
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DOI：
10.2460/javma.2002.221.1430
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发表时间：
2002-11-15
期刊：
影响因子：
--
通讯作者：
Solomon, JA
中科院分区：
文献类型：
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作者：
Weisse, C;Clifford, CA;Solomon, JA
术语温和动脉栓塞是指导管定向输送颗粒材料以栓塞选定动脉。该技术用于人类治疗多种疾病，包括动静脉畸形、子宫肌瘤和鼻出血。术语化疗栓塞是指选择性动脉内递送化疗剂与颗粒材料，目的是栓塞向肿瘤供血的动脉。与传统的药物递送模式相比，化疗栓塞增加了化疗剂的局部浓度和停留时间，增强了肿瘤缺血，并使全身毒性作用最小化。在人类中，该技术已显示出令人鼓舞的结果，在治疗各种不可切除的tumors.The本报告介绍了经皮温和动脉栓塞和化疗栓塞技术在狗和山羊和这些技术在3只狗和山羊的结果。对2只犬和1只山羊进行了动脉栓塞。治疗目标包括缓解疼痛、减少肿瘤生长和控制出血，根据术前目标，认为每只动物均从手术中获益。在1只犬中进行了化疗栓塞，以治疗不可切除的肝细胞癌。不幸的是，这只狗没有活足够长的时间来确定任何治疗反应。研究动物的结果说明了温和动脉栓塞和化疗栓塞在兽医患者中的可行性，并表明栓塞可能为患有不可手术病变的动物提供一种替代治疗方法。
The term bland arterial embolization refers to catheter-directed delivery of particulate material for the purpose of embolizing selected arteries. This technique is used in humans to treat a number of conditions, including arteriovenous malformations, uterine fibroids, and epistaxis. The term chemoembolization refers to selective intra-arterial delivery of chemotherapeutic agents in conjunction with particulate material for the purpose of embolizing arteries supplying blood to a tumor. Compared with traditional modes of drug delivery, chemoembolization increases local concentration and dwell time of the chemotherapeutic agent, augments tumor ischemia, and minimizes systemic toxic effects. In humans, the technique has shown encouraging results in the treatment of a variety of nonresectable tumors.The present report describes techniques for percutaneous bland arterial embolization and chemoembolization in dogs and goats and results of these techniques in 3 dogs and a goat. Bland arterial embolization was performed in 2 dogs and the goat. The goals of treatment included pain palliation, reduction of tumor growth, and control of hemorrhage, and each animal was considered to have benefited from the procedure on the basis of the preprocedural goals. Chemoembolization was performed in 1 dog for treatment of a nonresectable hepatocellular carcinoma. Unfortunately, this dog did not live long enough to identify any response to treatment. Results for animals studied illustrate the feasibility of bland arterial embolization and chemoembolization in veterinary patients and suggest that embolization may provide an alternative method of treatment for animals with inoperable lesions.