Nitric oxide: a neural messenger.
Nitric oxide: a neural messenger.
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DOI：
10.1146/annurev.cb.11.110195.002221
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发表时间：
1995
影响因子：
11.3
通讯作者：
S. Jaffrey;S. Snyder
中科院分区：
文献类型：
--
作者：
S. Jaffrey;S. Snyder
一氧化氮（NO）是一种信使分子，是目前在中枢和周围神经系统中公认的神经递质。一氧化氮最初被描述为“内皮来源的松弛因子”，随后被发现介导神经系统谷氨酸能刺激后cGMP的升高。药理学和免疫组织化学数据表明NO在全身有多种作用。NO敲除小鼠已经证明NO在行为和自主神经功能中是必不可少的。一氧化氮似乎还具有神经毒性和神经保护作用，并可能在中风和其他神经退行性疾病的发病机制中发挥作用。
Nitric oxide (NO) is a messenger molecule that is now a well established neurotransmitter in the central and peripheral nervous systems. NO was initially characterized as the "endothelium-derived relaxation factor" and subsequently found to mediate the elevation in cGMP following glutamatergic stimulation in the nervous system. Pharmacological and immunohistochemical data suggest numerous roles for NO throughout the body. NO knockout mice have demonstrated that NO is essential in behavioral and autonomic function. NO also appears to have neurotoxic and neuroprotective effects and may have a role in the pathogenesis of stroke and other neurodegenerative disorders.