Effects of microgravity on cell cytoskeleton and embryogenesis
Effects of microgravity on cell cytoskeleton and embryogenesis
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DOI：
10.1387/ijdb.052077sc
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发表时间：
2006-01-01
影响因子：
0.7
通讯作者：
Crawford-Young, SJ
中科院分区：
文献类型：
--
作者：
Crawford-Young, SJ
本审查的目的是汇编、总结和讨论微重力对胚胎、细胞结构和功能的影响，这些影响已从在空间或回转器引起的重力变化中进行的实验中获得的数据中得到证明。在微重力条件下，细胞和组织的细胞结构和遗传表达可能发生变化，这对胚胎发生产生各种影响，包括胚胎死亡、神经管闭合失败或新生儿或幼体总体形态最终畸形。许多物种和协议已用于微重力空间实验，因此难以比较结果。还可以进行关于在微重力下胚胎发育和细胞相互作用方式的实验。在微重力条件下对细胞所做的实验显示了形态、细胞骨架和功能的变化。已经注意到细胞骨架的变化，对微管在重力下的研究表明，它们对重力敏感。应当对细胞中发生的基本化学反应进行进一步研究，以便了解导致微重力下细胞和胚胎中观察到的变化的基本过程。
The aim of this review is to compile, summarize and discuss the effects of microgravity on embryos, cell structure and function that have been demonstrated from data obtained during experiments performed in space or in altered gravity induced by clinostats. In cells and tissues cellular structure and genetic expression may be changed in microgravity and this has a variety of effects on embryogenesis which include death of the embryo, failure of neural tube closure, or final deformities to the overall morphology of the newborn or hatchling. Many species and protocols have been used for microgravity space experiments making it difficult to compare results. Experiments on the ways in which embryonic development and cell interactions occur in microgravity could also be performed. Experiments that have been done with cells in microgravity show changes in morphology, cytoskeleton and function. Changes in cytoskeleton have been noted and studies on microtubules in gravity have shown that they are gravity sensitive. Further study of basic chemical reactions that occur in cells should be done to shed some light on the underling processes leading to the changes that are observed in cells and embryos in microgravity.