Non-invasive low-intensity pulsed ultrasound accelerates bone healing in the rabbit.
Non-invasive low-intensity pulsed ultrasound accelerates bone healing in the rabbit.
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DOI：
10.1097/00005131-199004030-00002
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发表时间：
1990-01-01
影响因子：
2.3
通讯作者：
Siffert, R S
中科院分区：
文献类型：
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作者：
Pilla, A A;Mont, M A;Siffert, R S
本研究评估了超声对139只成年新西兰大白兔腓骨截骨愈合率的影响。采用1毫米吉利锯进行双侧腓骨中轴截骨。US无创应用于一侧肢体，每天20分钟，而对侧肢体作为对照。一个2.5 cm的PZT换能器应用于四肢，治疗肢体接受200微秒的1.5 mhz正弦波脉冲，在1.0 kHz重复。入射强度约为30 mW/cm2。动物每隔14至28天被杀死一次。术后第14天至第23天，最大强度增加（p <或等于0.01）为40%至85%。第28天，各组的极限强度无显著差异。从第17天到第28天，所有us治疗的骨折与完整骨一样坚固（p小于或等于0.005）。另一方面，对照截骨术的最终强度仅在第28天达到完整值。这些结果表明，生物力学愈合加速了近1.7倍。在新骨折模型中，这种情况伴随着愈合曲线的整体加速而发生。如果无创低强度脉冲正弦波超声在临床应用中可以通过每天20分钟的家庭治疗显着加速骨修复，那么US可能是骨折护理的有用辅助，同时对患者的发病率有影响。
The effect of ultrasound (US) on the rate of fibula osteotomy healing in 139 mature New Zealand white rabbits was assessed in this study. Bilateral midshaft fibular osteotomies were made using a 1-mm Gigli saw. US was noninvasively applied to one limb for 20 minutes daily, while the contralateral limb served as a control. A 2.5-cm PZT transducer was applied to both limbs, with the treated limb receiving a 200-microseconds burst of 1.5-MHz sine waves repeated at 1.0 kHz. The incident intensity was approximately 30 mW/cm2. Animals were killed at intervals between 14 and 28 days. Maximum strength increases (significant to p less than or equal to 0.01) ranged from 40 to 85% from postoperative day 14 to 23. On day 28, no significant difference in ultimate strength was noted. From day 17 through day 28, all US-treated fractures were as strong as intact bones (p less than or equal to 0.005). On the other hand, the ultimate strength of the control osteotomies attained intact values only by day 28. These results indicate that biomechanical healing is accelerated by a factor of nearly 1.7. This occurs with an overall acceleration of the healing curve in this fresh fracture model. If noninvasive low-intensity pulsed sine wave ultrasound can significantly accelerate bone repair in clinical application with an in-home treatment of 20 minutes daily, then US may be a useful adjunct for fracture care with a concomitant impact on patient morbidity.