A comparison of three different methods to determine arterial compliance in the elderly: the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study
A comparison of three different methods to determine arterial compliance in the elderly: the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study
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DOI：
10.1097/01.hjh.0000226197.67052.89
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发表时间：
2006-06-01
影响因子：
4.9
通讯作者：
Stenborg, A
中科院分区：
文献类型：
--
作者：
Lind, L;Fors, N;Stenborg, A
背景：已经描述了几种不同的评估动脉顺应性的技术，但尚未在大规模、以人群为基础的环境中同时进行测试。本研究旨在评估这三种技术在老年人心血管系统前瞻性研究(PIVUS)中的可行性及其与心脏风险的关系。方法和结果在以人群为基础的PIVUS研究中(1016名70岁的参与者)，通过超声评估颈动脉的动脉扩张性，通过脉搏波分析(增强指数)和超声心动图测量每搏量/脉压比，分别有86，92，91和77%的样本获得成功。动脉顺应性的三个指标都是相互关联的(r=0.0001.19~0.34，P均<0.0 1)。在多元回归分析中，只有颈动脉扩张性和每搏量脉压比与Framingham危险评分独立相关(P<；0.0001)。结论在一般老年人群中，三项指标均可用于评价动脉顺应性，且相互关联。虽然所有技术都与Framingham风险评分相关，但只有颈动脉扩张性和每搏量/脉压比与冠状动脉风险独立相关，这表明未来这两个动脉顺应性指标可以互补使用。
Background Several different techniques to evaluate arterial compliance have been described but have not been simultaneously tested in a large-scale, population-based setting. This study aimed to evaluate the feasibility and relation to cardiac risk of three of these techniques in the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS) study.Methods and results In the population-based PIVUS study (1016 participants aged 70), assessment of arterial distensibility by ultrasound in the carotid artery, by pulse wave analysis (augmentation index) and the stroke volume to pulse pressure ratio by echocardiography were successfully employed in 86, 92, 91 and 77% of the sample, respectively. All three indices of arterial compliance were inter-related (r = 0.19-0.34, P < 0.0001 for all). Although all three indices were significantly related to the Framingham risk score (r = 0.12-0.32, P = 0.0005-0.0001), only carotid artery distensibility and the stroke volume to pulse pressure ratio were independently associated with the Framingham score in multiple regression analysis (P < 0.0001 for both).Conclusions All three indices to evaluate arterial compliance were feasible to obtain in a general elderly population and were inter-related. Although all of the techniques were correlated to Framingham risk score, only carotid artery distensibility and the stroke volume to pulse pressure ratio were independently related to coronary risk, suggesting complementary use of these two indices of arterial compliance in the future.