Prognostic value of lymphatic and blood vessel invasion in neuroendocrine tumors of the lung
Prognostic value of lymphatic and blood vessel invasion in neuroendocrine tumors of the lung
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DOI：
10.1097/01.pas.0000149706.74216.b6
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发表时间：
2005-03-01
影响因子：
5.6
通讯作者：
Geleff, S
中科院分区：
文献类型：
--
作者：
Schmid, K;Birner, P;Geleff, S
关于血管侵犯对神经内分泌肺肿瘤进展影响的数据很少。由于缺乏特异性标记物，之前的研究无法可靠地区分淋巴管和血管。通过对淋巴内皮特异性的足足蛋白和 CD34 抗原进行免疫染色，我们评估了 120 份肺神经内分泌肿瘤患者组织标本中的淋巴和血管侵袭情况。淋巴血管侵犯与临床病理参数相关，并评估其预后相关性。仅在肿瘤侵袭前沿发现了淋巴管，而在肿瘤内也看到了毛细血管。淋巴管以及淋巴管和血管侵犯在高级别神经内分泌肿瘤和晚期肿瘤患者中普遍存在，与淋巴结转移密切相关（P
Few data on the influence of vessel invasion on the progression of neuroendocrine lung tumors are available. Because of the lack of specific markers, previous studies could not reliably discriminate lymphatic and blood vessels. By immunostaining for podoplanin, specific for lymphatic endothelium, and CD34 antigen, we assessed lymphatic and blood vessel invasion in 120 tissue specimens of patients with neuroendocrine lung tumors. Lymphovascular invasion was correlated with clinicopathologic parameters, and its prognostic relevance was evaluated. Lymphatic vessels were identified exclusively at the tumor invasion front, whereas blood capillaries were also seen within tumors. Lymphatic vessel as well as lymphatic and blood vessel invasion was prevalent in patients with high-grade neuroendocrine tumors and advanced tumor stages, closely associated with lymph node metastases (P