INVITRO LOCALIZATION OF THERMOSENSITIVE NEURONS IN THE RAT DIENCEPHALON
INVITRO LOCALIZATION OF THERMOSENSITIVE NEURONS IN THE RAT DIENCEPHALON
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DOI：
10.1152/ajpregu.1989.257.1.r57
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发表时间：
1989-07-01
影响因子：
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通讯作者：
BOULANT, JA
中科院分区：
文献类型：
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作者：
DEAN, JB;BOULANT, JA
视前区-下丘脑前部（POAH）的许多热敏神经元被认为在体温调节中起作用。虽然间脑的许多其他区域也参与热调节，但缺乏对这些区域局部热刺激时单细胞活动的测量。利用水平组织切片，我们记录了整个大鼠间脑在局部热刺激下的单个活动。在18个细胞核中发现了热敏细胞。每个亚群在POAH内部和外部的比例相似：POAH （n = 83个细胞）；在POAH外（n = 198个细胞），warm = 31, cold = 4%, warm-cold = 1%, temperature insensitive = 64%；Warm = 39%, cold = 6%, Warm -cold = 4%, temperature insensitive = 51%。然而，位于吻侧和POAH外侧的细胞核含有大量的温敏细胞（49% -63%）。尾侧核包含了研究中大约一半的冷敏感细胞。这种广泛分布的热敏细胞表明，除了POAH外，间脑的许多区域也具有热接受和热整合的能力。此外，这些热敏细胞中的许多可能在其他系统中发挥作用（例如，繁殖，摄食和水平衡），这些系统已知会受到中心温度和环境温度的影响。
Many thermosensitive neurons in the preoptic area-anterior hypothalamus (POAH) are believed to function in thermoregulation. Although many other diencephalic regions are implicated in thermoregulation, measurements of single-cell activity during localized thermal stimulation in these regions are lacking. Utilizing horizontal tissues slices, we have recorded single-unit activity throughout the rat diencephalon in response to localized thermal stimulation. Thermosensitive cells were identified in 18 nuclei. The proportion of each subpopulation inside vs. outside the POAH were similar: POAH (n = 83 cells); warm = 31, cold = 4% warm-cold = 1%, and temperature insensitive = 64%, outside POAH (n = 198 cells); warm = 39%, cold = 6%, warm-cold = 4%, and temperature insensitive = 51%. However, nuclei located rostral and lateral to POAH contained a large percentage of warm-sensitive cells (49-63%). Caudal nuclei contained approximately half of the cold-sensitve cells studied. This wide distribution of thermosensitive cells suggests that many diencephalic areas, besides the POAH, are capable of thermoreception and thermointegration. Moreover, many of these thermosensitive cells may function in other systems (e.g., reproduction, feeding, and water balance) which central and environmental temperatures are known to influence.