The plasma glucose lowering action of tetrandrine in streptozotocin-induced diabetic rats
The plasma glucose lowering action of tetrandrine in streptozotocin-induced diabetic rats
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DOI：
10.1211/0022357023330
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发表时间：
2004-05-01
影响因子：
3.3
通讯作者：
Cheng, JT
中科院分区：
文献类型：
--
作者：
Chen, WC;Hayakawa, S;Cheng, JT
观察了粉防己有效成分粉防己碱对链脲佐菌素诱导的糖尿病大鼠血糖水平的影响。单次静脉注射粉防己碱可降低STZ糖尿病大鼠的血糖，且呈剂量依赖性。粉防己碱（1.0 mg kg ~（-1））能显著抑制正常大鼠静脉葡萄糖激发试验引起的血糖升高。汉防己甲素对葡萄糖摄取的刺激作用，从STZ-糖尿病大鼠分离的比目鱼肌中获得的浓度依赖性的方式从0.01至10.0 μ mol L-1。汉防己甲素增加葡萄糖利用率的进一步特点是使用链脲佐菌素糖尿病大鼠肝细胞中糖原合成的增强。这些结果表明粉防己碱具有增强外周组织葡萄糖利用的能力，从而降低缺乏胰岛素的糖尿病大鼠的血糖。
The effect of tetrandrine, an active principle of Stephaniae tetrandrae, on the plasma glucose level in streptozotocin-induced diabetic rats (STZ-diabetic rats) was investigated. A single intravenous injection of tetrandrine decreased the plasma glucose in a dose-dependent manner in STZ-diabetic rats. Moreover, tetrandrine (1.0 mg kg(-1)) significantly attenuated the rise in plasma glucose induced by the intravenous glucose challenge test in normal rats. A stimulatory effect of tetrandrine on glucose uptake was obtained in soleus muscles isolated from STZ-diabetic rats with a concentration-dependent manner from 0.01 to 10.0 mumol L-1. The increase in glucose utilization by tetrandrine was further characterized using the enhancement of glycogen synthesis in the hepatocytes of STZ-diabetic rats. These results suggest that tetrandrine has the ability to enhance glucose utilization in peripheral tissue, resulting in the lowering of plasma glucose in diabetic rats lacking insulin.