Variation in Recovery Role of Gender on Outcomes of Young AMI Patients (VIRGO) Study Design
Variation in Recovery Role of Gender on Outcomes of Young AMI Patients (VIRGO) Study Design
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DOI：
10.1161/circoutcomes.109.928713
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发表时间：
2010-11-01
影响因子：
6.9
通讯作者：
Krumholz, Harlan M.
中科院分区：
文献类型：
--
作者：
Lichtman, Judith H.;Lorenze, Nancy P.;Krumholz, Harlan M.
背景-在缺血性心脏病患者中，患有急性心肌梗死（AMI）的年轻女性代表了与过高死亡风险相关的极端表型。尽管年龄小于55岁的女性占住院AMI事件的不到5%，但该群体每年报告的死亡人数接近16000人，使心脏病成为年轻女性的主要杀手。尽管有较高的死亡风险相比，同样年龄的男性，年轻女性一直是少数研究的主题。方法和结果的变化恢复：年轻AMI患者（处女座）的结果性别的作用是一个大型的，观察性研究的介绍，治疗和结果的年轻女性和男性AMI。VIRGO将从100多家参与医院招募2000名年龄在18至55岁之间的AMI女性患者和1000名AMI男性患者作为对照组。本研究的目的是确定生物学、人口统计学、临床和心理社会危险因素的分布和预后重要性的性别差异;确定年轻AMI患者接受的护理质量是否存在性别差异;并确定这些因素如何导致结局（包括死亡率、住院率和健康状况）的性别差异。同意参与者的血清和DNA将被存储为未来的study. Conclusions处女座将寻求确定新的和预后因素，有助于在这个年轻的AMI人群的结果。研究结果将用于为年轻AMI患者开发临床有用的风险分层模型，解释结局的性别差异，并确定干预目标。(Circ血管定性结局。2010;3：684-693.）
Background-Among individuals with ischemic heart disease, young women with an acute myocardial infarction (AMI) represent an extreme phenotype associated with an excess mortality risk. Although women younger than 55 years of age account for less than 5% of hospitalized AMI events, almost 16 000 deaths are reported annually in this group, making heart disease a leading killer of young women. Despite a higher risk of mortality compared with similarly aged men, young women have been the subject of few studies.Methods and Results-Variation in Recovery: Role of Gender on Outcomes of Young AMI Patients (VIRGO) is a large, observational study of the presentation, treatment, and outcomes of young women and men with AMI. VIRGO will enroll 2000 women, 18 to 55 years of age, with AMI and a comparison cohort of 1000 men with AMI from more than 100 participating hospitals. The aims of the study are to determine sex differences in the distribution and prognostic importance of biological, demographic, clinical, and psychosocial risk factors; to determine whether there are sex differences in the quality of care received by young AMI patients; and to determine how these factors contribute to sex differences in outcomes (including mortality, hospitalization, and health status). Blood serum and DNA for consenting participants will be stored for future studies.Conclusions-VIRGO will seek to identify novel and prognostic factors that contribute to outcomes in this young AMI population. Results from the study will be used to develop clinically useful risk-stratification models for young AMI patients, explain sex differences in outcomes, and identify targets for intervention. (Circ Cardiovasc Qual Outcomes. 2010;3:684-693.)