Predicting Preterm Birth Using Cell-Free Ribonucleic Acid
Predicting Preterm Birth Using Cell-Free Ribonucleic Acid
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DOI：
10.1016/j.clp.2024.02.008
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发表时间：
2024-05-03
影响因子：
2.1
通讯作者：
Tribe，Rachel M.
中科院分区：
文献类型：
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作者：
Cowan，Alison D.;Rasmussen，Morten;Tribe，Rachel M.
自发性早产（sPTB）是一种复杂的临床异质性疾病，目前尚不完全清楚，导致干预措施不足以有效预防其发生。母体循环中的无细胞核糖核酸特征具有鉴定sPTB的生物学相关亚型的潜力。有一天，这些可以用来预测和预防无症状个体的sPTB，并帮助预测和管理有先兆早产和早产前胎膜破裂的个体。
Spontaneous preterm birth (sPTB) is a complex and clinically heterogeneous condition that remains incompletely understood, leading to insufficient interventions to effectively prevent it from occurring. Cell-free ribonucleic acid signatures in the maternal circulation have the potential to identify biologically relevant subtypes of sPTB. These could one day be used to predict and prevent sPTB in asymptomatic individuals, and to aid in prognosis and management for individuals presenting with threatened preterm labor and preterm prelabor rupture of membranes.