Stem cells and diabetic cardiomyopathy: from pathology to therapy
Stem cells and diabetic cardiomyopathy: from pathology to therapy
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干细胞和糖尿病心肌病：从病理学到治疗
DOI：
10.1007/s10741-016-9565-4
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发表时间：
2016-11-01
影响因子：
4.6
通讯作者：
Wang, Jian'an
中科院分区：
文献类型：
--
作者：
Liu, Mingfei;Chen, Han;Wang, Jian'an
世界范围内糖尿病患病率上升的趋势突出表明，有必要加大研究力度，研究疾病本身及其相关并发症的治疗方案。糖尿病已被广泛认为是心血管疾病的主要危险因素，如冠心病和高血压。糖尿病心肌病(DCM)是糖尿病的主要并发症，可导致不依赖于缺血或高血压的特殊形式的心力衰竭。如果没有相当有效的方法，迫切需要进一步探索预防或逆转DCM进展的机制和潜在的治疗策略。在过去的几十年里，基于干细胞的疗法对包括扩张型心肌炎在内的各种疾病都有希望。本文就糖尿病心肌病的病理变化、糖尿病内源性干细胞和外源性干细胞移植治疗扩张型心肌病的研究现状进行综述。如果充分利用干细胞的优势，明确探讨干细胞的作用机制，基于干细胞的治疗可以成为预防和治疗DCM患者的重要工具。
The worldwide increase trend in the prevalence of diabetes has highlighted the need for increased research efforts into treatment options for both the disease itself and its associated complications. Diabetes has been widely recognized as a major risk factor for cardiovascular diseases, such as coronary heart disease and hypertension. Diabetic cardiomyopathy (DCM) is a main complication of diabetes, contributing to specific forms of heart failure independent from ischemia or hypertension. Without considerably effective approaches, a dire need exists to further explore the mechanisms and potential therapeutic strategies to prevent or reverse the progression of DCM. In the past decades, stem cell-based therapies have held promises to various diseases including DCM. The aim of the present review was to summarize the current literature with regard to the pathological changes of diabetic cardiomyopathy, endogenous stem cells in diabetes, and the exogenous stem cells transplantation for DCM. If the best use is made of the advantages of stem cells and their mechanism of action is explicitly explored, stem cell-based therapies could served as an important tool for the prevention and treatment of DCM patients.