Inhibition of angiogenesis by blocking activation of the vascular endothelial growth factor receptor 2 leads to decreased growth of neurogenic sarcomas.
Inhibition of angiogenesis by blocking activation of the vascular endothelial growth factor receptor 2 leads to decreased growth of neurogenic sarcomas.
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发表时间：
1999-11
期刊：
影响因子：
11.2
通讯作者：
L. Angelov;B. Salhia;Luba Roncari;G. Mcmahon;A. Guha
中科院分区：
文献类型：
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作者：
L. Angelov;B. Salhia;Luba Roncari;G. Mcmahon;A. Guha
神经源性肉瘤是一种常见的恶性外周神经肿瘤，易发生局部复发和全身转移。在这项研究中，血管，血管内皮生长因子（VEGF）的表达，以及抑制VEGF受体对神经源性肉瘤生长的影响进行了研究。肿瘤中血管化和VEGF表达分别是正常神经的6.4倍和15倍。VEGF受体2的小分子抑制剂（SU5416）在体外对神经源性肉瘤细胞系没有影响，但与载体相比，人肿瘤外植体异种移植模型的生长减少了54.8%。肿瘤生长的减少是由于肿瘤血管生成减少，导致肿瘤细胞增殖减少和凋亡增加。因此，抑制VEGF的功能可能是一个有用的辅助治疗神经源性肉瘤。
Neurogenic sarcomas are incurable, common malignant human peripheral nerve tumors subject to local recurrence and systemic metastasis. In this study, the vascularity, vascular endothelial growth factor (VEGF) expression, and effects of inhibiting VEGF receptor on growth of neurogenic sarcomas were examined. Vascularization and VEGF expression were 6.4- and 15-fold higher in tumors than in normal nerves. The small molecule inhibitor (SU5416) of VEGF receptor 2 had no effect on neurogenic sarcoma cell lines in vitro, but the growth of a human tumor explant xenograft model was reduced by 54.8% compared to vehicle. Reduction in tumor growth was due to decreased tumor angiogenesis, leading to reduction of tumor cell proliferation and increased apoptosis. Inhibiting VEGF function may therefore be a useful adjuvant therapy for neurogenic sarcomas.