A novel type of non-coding RNA expressed in the rat brain
A novel type of non-coding RNA expressed in the rat brain
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DOI：
10.1016/s0169-328x(98)00343-x
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发表时间：
1999-03-20
期刊：
影响因子：
--
通讯作者：
Yamamori, T
中科院分区：
文献类型：
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作者：
Komine, Y;Tanaka, NK;Yamamori, T
我们已经表征了一种新型非编码 RNA，它由相似序列的串联重复组成，大小约为 0.9 kb。这种 RNA 被称为 Bsr（脑特异性重复）RNA，在大鼠基因组中的单个基因座 (6 q31 --> q32) 上编码，其中 100 至 150 个 0.9 kb 序列的拷贝串联重复。 Bsr RNA 优先在大鼠中枢神经系统 (CNS) 中表达，特别是在系统发育古老的结构中，例如顶皮层和古皮层、杏仁核、丘脑和下丘脑。在发育中的大脑中，Bsr RNA 在分化细胞亚群中表达，但在增殖细胞中不表达。尽管发现 Bsr RNA 似乎仅在黄鼠物种中保守，但 Bsr RNA 的特定表达模式表明它可能在大鼠 CNS 中发挥一定作用。 (C) 1999 Elsevier Science B.V. 保留所有权利。
We have characterized a novel type of non-coding RNA which consists of tandem repeats of similar sequences, approximately 0.9 kb in size. This RNA, termed Bsr (brain specific repetitive) RNA, is encoded at a single locus (6 q31 --> q32) in the rat genome, where 100 to 150 copies of the 0.9 kb sequences are repeated in tandem. Bsr RNA is preferentially expressed in the rat central nervous system (CNS), especially in phylogenetically old structures, such as the pareo- and archicortex, amygdala, thalamus and hypothalamus. In the developing brains, Bsr RNA is expressed in the subsets of differentiating cells but not in proliferating cells. Despite the finding that Bsr RNA appears to be conserved only among the Rattus species, the specific expression pattern of Bsr RNA suggests that it might have some role in the rat CNS. (C) 1999 Elsevier Science B.V. All rights reserved.