The relationship between syndromes of the psychotic illness and familial liability to schizophrenia and major mood disorders
The relationship between syndromes of the psychotic illness and familial liability to schizophrenia and major mood disorders
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DOI：
10.1016/j.schres.2006.12.018
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发表时间：
2007-03
影响因子：
4.5
通讯作者：
V. Peralta;M. Cuesta
中科院分区：
文献类型：
--
作者：
V. Peralta;M. Cuesta
背景以前的研究探讨了精神病的精神病理学综合征与精神分裂症和心境障碍的家族易感性之间的关系，得到了不确定的结果。本研究的目的是通过分析大样本的精神病先证者和他们的一级亲属，以进一步探讨这一问题。先证者被评估为指数发作和终身症状，而亲属被评估为精神分裂症和主要情绪障碍的终身诊断。先证者因子分析衍生的综合征与精神分裂症和主要心境障碍的家族负荷之间的关联进行了测试。先证者的阴性综合征可预测精神分裂症的家族发病风险，先证者的躁狂、抑郁和紧张综合征可预测心境障碍的家族发病风险。这种关联模式相对独立于症状评定类型（指数发作或终生）和先证者对精神分裂症或严重心境障碍的诊断。精神分裂症和心境障碍的家庭负荷切割跨DSM-IV类精神障碍的先证者。CONCLUSIONFrom a dimensional perspective，阴性综合征与发展为精神分裂症的家庭倾向有关。躁狂症、抑郁症和紧张症综合征与家族易患严重心境障碍有关。精神障碍的类别是对精神分裂症和主要情绪障碍的家族易感性的连续统一体。
BACKGROUNDPrevious studies examining the relationship between psychopathological syndromes of the psychotic illness and familial liability to schizophrenia and mood disorders have obtained inconclusive results. The aim of this study is to further examine this issue by analyzing a large sample of psychotic probands and their first-degree relatives.METHODSThe sample was composed of 660 psychotic inpatients and their 2987 first-degree relatives. Probands were assessed for index episode and lifetime symptoms, while relatives were assessed for lifetime diagnosis of schizophrenia and major mood disorders. Associations between factor-analysis derived syndromes in probands and familial loading for schizophrenia and major mood disorders were tested.RESULTSFamilial morbid risk of schizophrenia was predicted by the negative syndrome in probands and familial morbid risk of mood disorders was predicted by mania, depression and catatonia syndromes in probands. This association pattern was relatively independent of type of symptom rating (index episode or lifetime) and probands' diagnosis of schizophrenia or major mood disorder. Familial loading for schizophrenia and mood disorders cut-across the DSM-IV categories of psychotic disorders in probands.CONCLUSIONFrom a dimensional perspective, the negative syndrome is related to familial liability to develop schizophrenia. Mania, depression and catatonia syndromes are related to the familial liability to develop major mood disorders. Categories of psychotic disorders are on a continuum of familial liability to schizophrenia and major mood disorders.