Recipient and Donor Body Mass Index as Important Risk Factors for Delayed Kidney Graft Function
Recipient and Donor Body Mass Index as Important Risk Factors for Delayed Kidney Graft Function
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DOI：
10.1097/tp.0b013e318243c6e4
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发表时间：
2012-03-15
期刊：
影响因子：
6.2
通讯作者：
Oellinger, Robert
中科院分区：
文献类型：
--
作者：
Weissenbacher, Annemarie;Jara, Maximilian;Oellinger, Robert
背景。肥胖对整体健康状况和全球医疗保健成本的影响越来越大。在同种异体肾脏移植受者和已故器官捐献者中也观察到体重指数 (BMI) 的增加。方法。在一项回顾性单中心研究中，我们分析了 2000 年至 2009 年间在我们机构移植的 1132 例死亡供肾移植物，了解受者和供者 BMI 及其与延迟移植物功能 (DGF) 的相关性。受赠者/捐献者根据体重指数（30 kg/m(2)）进行分类。 DGF 被定义为移植后第一周内需要进行一次透析。结果。总体 DGF 率为 32.4%，平均受者 BMI 为 23.64 +/- 3.75 kg/m(2)，平均捐赠者 BMI 为 24.69 +/- 3.44 kg/m(2)。 BMI小于18.5、18.5～24.9、25～29.9和大于30 kg/m(2)的受者的DGF率分别为25.2%、29.8%、40.9%和52.6%(P < 0.0001)。供体BMI小于18.5、18.5至24.9、25至29.9、大于30 kg/m(2)时，DGF率分别为22.5%、31.0%、37.3%和51.2%（P < 0.0001）。多变量分析显示受者 BMI 和透析持续时间是 DGF 的独立危险因素。 DGF 导致 1 年和 5 年移植物存活率和患者存活率较差。结论。受者和供者的 BMI 与 DGF 的发生率相关。对此的认识应该会对肾移植受者的移植前后措施产生影响。
Background. Obesity is increasingly impacting the overall health status and the global costs for health care. The increase in body mass index (BMI) is also observed in kidney allograft recipients and deceased organ donors.Methods. In a retrospective single-center study, we analyzed 1132 deceased donor kidney grafts, transplanted at our institution between 2000 and 2009 for recipient and donor BMI and its correlation with delayed graft function (DGF). Recipients/donors were classified according to their BMI (30 kg/m(2)). DGF was defined as requirement for one dialysis within the first week after transplantation.Results. Overall DGF rate was 32.4%, mean recipient BMI was 23.64 +/- 3.75 kg/m(2), and mean donor BMI was 24.69 +/- 3.44 kg/m(2). DGF rate was 25.2%, 29.8%, 40.9%, and 52.6% in recipients with BMI less than 18.5, 18.5 to 24.9, 25 to 29.9, and more than 30 kg/m(2), respectively (P < 0.0001). Donor BMI less than 18.5, 18.5 to 24.9, 25 to 29.9, more than 30 kg/m(2) resulted in a DGF rate of 22.5%, 31.0%, 37.3%, and 51.2% (P < 0.0001). Multivariate analysis revealed recipient BMI and dialysis duration as independent risk factors for DGF. DGF results in inferior 1- and 5-year graft and patient survival.Conclusion. Recipient and donor BMI correlate with the incidence of DGF. Awareness thereof should have an impact on peri-and posttransplant measures in renal transplant recipients.