Evidence for the involvement of the organum vasculosum laminae terminalis in the febrile response of rabbits and rats.
Evidence for the involvement of the organum vasculosum laminae terminalis in the febrile response of rabbits and rats.
复制标题
终板血管器官参与兔和大鼠发热反应的证据。
DOI：
10.1113/jphysiol.1985.sp015872
复制
发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Stitt,JT
中科院分区：
文献类型：
--
作者：
Stitt,JT
在暴露于各自热中温环境温度的兔和大鼠组中，确定了静脉注射内源性热原的对照发热反应。离散的电解性损伤被放置在终板血管器的范围内(o.v.l.t.)每一物种的。3天后，动物的发热反应被重新测量，在每个病例中，使用与之前使用的相同剂量的内源性热原，产生的发热都有明显的增强。在对照组动物中，单侧放置在视前区下丘脑前部的类似病变在增强这些动物的发热反应方面并不有效。在接下来的3周内，研究了这种病变引起的兔发热增强的过程，发现它逐渐恢复到对照水平。据推测，o.v.l.t.以某种方式参与循环热原转化为发热刺激的过程。位于该区域的病变被认为要么增加了进入卵巢的热原的量，要么增加了卵巢内热原受体位置的敏感性。
Control febrile responses to intravenous injections of endogenous pyrogen were determined in groups of rabbits and rats, exposed to their respective thermoneutral ambient temperatures. Discrete electrolytic lesions were placed within the confines of the organum vasculosum laminae terminalis (o.v.l.t.) of each species. The fever responses of the animals were remeasured 3 days later, and in every case there was a marked enhancement of the fevers produced, using the same doses of endogenous pyrogen that were used earlier. Similar lesions that were placed unilaterally within the preoptic anterior hypothalamic area in groups of control animals, were not effective in enhancing the febrile responses of these animals. The course of this lesion‐induced fever enhancement in rabbits was studied during the succeeding 3 week period, when it was found to return gradually towards the control levels. It is postulated that the o.v.l.t. is involved in some manner in the process whereby circulating pyrogen is translated into a febrile stimulus. Lesions posited within this region are thought to either increase the amount of pyrogen entering the o.v.l.t., or to increase the sensitivity of pyrogen receptor sites within the o.v.l.t.