Angelica acutiloba Exerts Antihypertensive Effect and Improves Insulin Resistance in Spontaneously Hypertensive Rats Fed with a High-Fat Diet
Angelica acutiloba Exerts Antihypertensive Effect and Improves Insulin Resistance in Spontaneously Hypertensive Rats Fed with a High-Fat Diet
复制标题
DOI：
10.1159/000520982
复制
发表时间：
2022-01-17
期刊：
影响因子：
3.1
通讯作者：
Nakata，Tetsuo
中科院分区：
文献类型：
--
作者：
Watanabe，Yusuke;Nessa，Naseratun;Nakata，Tetsuo
前言尖叶当归是我国常用的中草药之一，其摄入有望改善代谢综合征相关疾病。在这里，我们研究了A.本研究旨在探讨尖瓣叶提取物（AAE）对高脂饮食（HFD）诱导的自发性高血压大鼠（SHR）高血压及胰岛素抵抗的影响。然后，我们研究了与AAE.MethodsAAE的影响相关的机制给予HFD喂养的SHR。结果AAE降低了HFD喂养的SHR的收缩压和下丘脑血管紧张素转换酶（ACE）活性的增加，并降低了HFD喂养的SHR的收缩压和下丘脑ACE活性的增加。而对交感神经活动的抑制作用轻微。环境应激引起的压力和交感神经过度活动被AAE的治疗所抑制。AAE还降低了血糖水平、血浆胰岛素浓度、胰岛素抵抗的稳态模型评估以及内脏脂肪中TNF-α基因表达的增加，但不增加内脏脂肪mass.ConclusionAAE具有抗高血压作用，抑制应激性高血压，改善HFD喂养的SHR的胰岛素抵抗。AAE对脑ACE活性、交感神经活性和炎症的抑制部分参与了AAE的作用。
IntroductionAngelica acutiloba is one of the crude drugs used in Chinese herbal medicine, and its intake is expected to improve metabolic syndrome-associated disorders. Here, we examined the effects of A. acutiloba extract (AAE) on hypertension and insulin resistance induced by the treatment of high-fat diet (HFD) to spontaneously hypertensive rats (SHRs). Then, we investigated the mechanisms associated with the effects of AAE.MethodsAAE was administered to HFD-fed SHRs. Systolic blood pressure (SBP), sympathetic nerve activity, hypothalamic angiotensin-converting enzyme (ACE) activity, blood glucose level, plasma insulin concentration, visceral fat mass, and gene expression of tumor necrosis factor-alpha (TNF-α) in the visceral fat were evaluated.ResultsAAE reduced the increases in SBP and hypothalamic ACE activity observed in the HFD-fed SHRs, whereas the suppressive effect on sympathetic nerve activity was slight. Environmental stress-induced pressure and sympathetic overactivity were suppressed by the treatment of AAE. It also decreased the increase in the blood glucose level, plasma insulin concentration, homeostasis model assessment for the insulin resistance, and TNF-α gene expression in the visceral fat, but not the increase in the visceral fat mass.ConclusionAAE has an antihypertensive effect, suppresses stress-induced hypertension, and improves insulin resistance in HFD-fed SHRs. The suppression of brain ACE activity, sympathetic nerve activity, and inflammation are partly involved in the effects of AAE.