Prospective Echocardiography Assessment of Pulmonary Hypertension and Its Potential Etiologies in Children With Sickle Cell Disease
Prospective Echocardiography Assessment of Pulmonary Hypertension and Its Potential Etiologies in Children With Sickle Cell Disease
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DOI：
10.1016/j.amjcard.2009.04.034
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发表时间：
2009-09-01
影响因子：
2.8
通讯作者：
Sable, Craig
中科院分区：
文献类型：
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作者：
Dham, Niti;Ensing, Gregory;Sable, Craig
肺动脉高压（PH）与成人镰状细胞病（SCD）的不良结局相关，但其在儿童中的重要性尚不清楚。本研究的目的是确定SCD儿童患者PH的发生率和原因。SCD儿童（n = 310）和匹配的对照组（n = 54）在基础条件下前瞻性入组。参与者接受了超声心动图、脉搏血氧仪、6分钟步行试验和血液学检测。在校正血红蛋白前后，比较SCD患者和对照组的超声心动图测量结果。确定超声心动图和临床参数的相关性。与对照组相比，三尖瓣返流速度（TRV）升高（2.28 vs 2.10 m/s，p
Pulmonary hypertension (PH) is associated with adverse outcomes in adults with sickle-cell disease (SCD), but its importance in children is less clear. The aim of this study was to define the incidence and causes of PH in pediatric patients with SCD. Children with SCD (n = 310) and matched controls (n = 54) were prospectively enrolled under basal conditions. Participants underwent echocardiography, pulse oximetry, 6-minute walk tests, and hematologic testing. Echocardiographic measures were compared between patients with SCD and control subjects before and after adjusting for hemoglobin. Correlations of echocardiographic and clinical parameters were determined. Tricuspid regurgitation velocity (TRV) was elevated compared to controls (2.28 vs 2.10 m/s, p