Survival after lobectomy versus sub-lobar resection in elderly with stage I NSCLC: a meta-analysis
Survival after lobectomy versus sub-lobar resection in elderly with stage I NSCLC: a meta-analysis
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老年 I 期 NSCLC 患者肺叶切除术与亚肺叶切除术后的生存率：一项荟萃分析
DOI：
10.1186/s12893-019-0500-1
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发表时间：
2019-04-15
期刊：
影响因子：
1.9
通讯作者：
Xu, Shun
中科院分区：
文献类型：
--
作者：
Dong, Siyuan;Roberts, Steven A.;Xu, Shun
背景：我们采用荟萃分析技术对老年早期非小细胞肺癌患者的肺叶切除术和亚肺叶切除术进行了比较。方法检索1997年12月至2019年3月期间的文献，以确定评估1年、3年和5年生存率的比较研究。分别用固定效应模型和随机效应模型计算合并优势比（OR）和95%置信区间（95% CI）。结果我们的荟萃分析纳入了6项回顾性研究，共1205例患者。843例行肺叶切除术，362例行亚肺叶切除术。我们发现肺叶切除术和亚肺叶切除术在1年、3年或5年生存率上没有显著差异。本研究表明，在老年I期NSCLC患者中，在1、3和5年生存率方面，叶下切除术与肺叶切除术在统计学上是相等的。需要进一步的大规模随机研究来证实我们的结果。
BackgroundWe present a critical comparison of lobectomy and sub-lobar resection in elderly patients with early stage non-small cell lung cancer using meta-analytical techniques.MethodsA literature search was conducted between the period of December 1997 to March 2019 to identify the comparative studies evaluating 1-, 3-, and 5-year survival rates. The pooled odds ratios (OR) and the 95% confidence intervals (95% CI) were calculated with either the fixed or random effect models, respectively.ResultsSix retrospective studies are included in our meta-analysis for a total of 1205 patients. 843 of the individuals were treated with lobectomy, while 362 were treated with sub-lobar resection. We found no significant difference between the lobectomy and the sub-lobar resection in either of the 1-, 3-, or 5-year survival rates.ConclusionsThis study suggests that in elderly individuals with stage I NSCLC, a sub-lobar resection is statistically equivalent to the lobectomy in terms of 1-, 3-, and 5-year survival rates. Further large-scale randomized studies are needed to confirm our results.