CDH1 gene polymorphisms, smoking, Helicobacter pylori infection and the risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST)
CDH1 gene polymorphisms, smoking, Helicobacter pylori infection and the risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST)
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DOI：
10.1016/j.ejca.2008.02.003
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发表时间：
2008-04-01
影响因子：
8.4
通讯作者：
Gonzalez, Carlos
中科院分区：
文献类型：
--
作者：
Jenab, Mazda;McKay, James D.;Gonzalez, Carlos
尽管发病率下降，但胃癌（GC）仍是全球范围内的主要死亡原因。E-钙粘蛋白是一种粘附分子，被认为与GC有关。在遗传性弥漫性GC中已发现E-钙粘蛋白基因（CDH 1）的种系突变。此外，在位置160 C/A的启动子多态性已被建议导致转录下调，并已被证明在一些研究中影响GC风险。然而，关于其他CDH 1多态性与GC风险相关性的信息非常少，目前还不清楚是否有任何相关性可能因GC解剖部位或组织学类型而不同。因此，在欧洲癌症与营养前瞻性研究（EPIC）队列中进行了一项病例对照研究（病例= 245/对照= 950），以评估8种CDH 1基因多态性与GC风险的相关性。没有CDH 1多态性或单倍型分析与GC的风险和幽门螺杆菌感染状态没有观察到差异的影响。然而，在同一个单倍型区块中的三个CDH 1多态性，包括CDH 1 - 160 C/A，与吸烟相互作用，增加吸烟者的GC风险，但不吸烟者。这些发现应该在更大规模的独立研究中得到证实。(c)2008爱思唯尔有限公司保留所有权利。
Despite declining incidence rates, gastric cancer (GC) is a major cause of death worldwide. E-Cadherin is an adhesion molecule that is thought to be involved in GC. Germline mutations in the E-Cadherin gene (CDH1) have been identified in hereditary diffuse GC. Also, a promoter polymorphism at position 160 C/A has been suggested to lead to transcriptional down regulation and has been shown to affect GC risk in some studies. However, very little information exists on the GC risk association of other CDH1 polymorphisms and it is unclear whether any associations may be different by GC anatomical sites or histological types. Thus, a case-control study (cases = 245/controls = 950) nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort was conducted to assess the GC risk association of eight CDH1 gene polymorphisms. None of the CDH1 polymorphisms or haplotypes analysed were associated with GC risk and no differences of effect were observed by Helicobacter pylori infection status. However, three CDH1 polymorphisms in the same haplotype block, including the CDH1-160C/A, interacted with smoking to increase GC risk in smokers but not in never smokers. These findings should be confirmed in larger independent studies. (c) 2008 Elsevier Ltd. All rights reserved.